National HIV/AIDS Research Center, Istituto Superiore di Sanità, Rome, Italy.
Department of Veterinary Medicine, University of Sassari, Sassari, Italy.
J Med Virol. 2022 Apr;94(4):1257-1260. doi: 10.1002/jmv.27519. Epub 2021 Dec 19.
The ongoing discussion about the real origin of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) feeds acrimonious debates. Where did SARS-CoV-2 come from? Was SARS-CoV-2 transmitted in the wild from an animal to a person before exploding in Wuhan or was it an engineered virus that escaped from research or a laboratory in Wuhan? Right now, we still don't know enough whether SARS-CoV-2 is human-made or not, and lab-leak theories remain essentially speculative. Many recent studies have pointed out several plausible scenarios. Anyhow, currently, even if suspicions by some about the possibility of lab-leak hypothesis still remain, the consensus view is that the pandemic probably started from a natural source and, to determine the real origin of the SARS-CoV-2 virus, further research is needed.
目前,关于严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)的真实起源仍存在激烈的争论。SARS-CoV-2 源自何处?在武汉大爆发之前,SARS-CoV-2 是否是从野生动物传播给人类的,还是一种从武汉的研究或实验室逃逸出来的工程病毒?目前,我们仍然不太清楚 SARS-CoV-2 是否是人为制造的,实验室泄漏理论仍然基本上是推测性的。最近的许多研究都指出了几种合理的情况。无论如何,目前,即使有些人对实验室泄漏假说的可能性仍持怀疑态度,但共识观点是,大流行可能是从自然来源开始的,为了确定 SARS-CoV-2 病毒的真正起源,需要进一步研究。