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水稻条纹病毒激活未折叠蛋白反应信号通路中的 bZIP17/28 分支，促进病毒感染。

Rice stripe virus activates the bZIP17/28 branch of the unfolded protein response signalling pathway to promote viral infection.

机构信息

State Key Laboratory of Rice Biology, Institute of Biotechnology, Zhejiang University, Hangzhou, China.

Key Laboratory of Food Quality and Safety, Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Nanjing, China.

出版信息

Mol Plant Pathol. 2022 Mar;23(3):447-458. doi: 10.1111/mpp.13171. Epub 2021 Dec 11.

DOI:10.1111/mpp.13171
PMID:34897936
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8828695/
Abstract

The unfolded protein response (UPR) plays important roles in plant virus infection. Our previous study has proved that rice stripe virus (RSV) infection elicits host UPR. However, the mechanism on how the UPR is triggered upon RSV infection remains obscure. Here, we show that the bZIP17/28 branch of the UPR signalling pathway is activated upon RSV infection in Nicotiana benthamiana. We found that membrane-associated proteins NSvc2 and NSvc4 encoded by RSV are responsible for the activation of the bZIP17/28 branch. Ectopic expression of NSvc2 or NSvc4 in plant leaves induced the proteolytic processing of NbbZIP17/28 and up-regulated the expression of UPR-related genes. Silencing NbbZIP17/28 significantly inhibited RSV infection. We show that RSV can specifically elicit the UPR through the bZIP17/28 branch, thus promoting virus infection of N. benthamiana plants.

摘要

未折叠蛋白反应（UPR）在植物病毒感染中发挥重要作用。我们之前的研究已经证明，水稻条纹病毒（RSV）感染会引发宿主 UPR。然而，关于 RSV 感染如何引发 UPR 的机制仍不清楚。在这里，我们发现在 RSV 感染烟草原生质体中，UPR 信号通路的 bZIP17/28 分支被激活。我们发现 RSV 编码的膜相关蛋白 NSvc2 和 NSvc4 负责激活 bZIP17/28 分支。在植物叶片中异位表达 NSvc2 或 NSvc4 诱导 NbbZIP17/28 的蛋白水解加工，并上调 UPR 相关基因的表达。沉默 NbbZIP17/28 显著抑制 RSV 感染。我们表明 RSV 可以通过 bZIP17/28 分支特异性地引发 UPR，从而促进 RSV 在烟草原生质体植物中的感染。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8755/8828695/65029f17af1f/MPP-23-447-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8755/8828695/74259dc3f348/MPP-23-447-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8755/8828695/6f10c367b9c4/MPP-23-447-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8755/8828695/9ec73d93aae3/MPP-23-447-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8755/8828695/7124e4a5de73/MPP-23-447-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8755/8828695/e3249115f843/MPP-23-447-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8755/8828695/65029f17af1f/MPP-23-447-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8755/8828695/74259dc3f348/MPP-23-447-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8755/8828695/6f10c367b9c4/MPP-23-447-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8755/8828695/9ec73d93aae3/MPP-23-447-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8755/8828695/7124e4a5de73/MPP-23-447-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8755/8828695/e3249115f843/MPP-23-447-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8755/8828695/65029f17af1f/MPP-23-447-g005.jpg

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