Department of Physiology, R.D.Gardi Medical College, Ujjain, India.
Center for Brain and Cognition, UC San Diego, San Diego, USA.
J Basic Clin Physiol Pharmacol. 2020 Nov 19;32(6):1075-1082. doi: 10.1515/jbcpp-2020-0210.
Vestibular nerve stimulation using the portable battery-operated vestibular nerve stimulator is a sophisticated method noninvasive, safe, and easy to operate. It was hypothesized that vestibular nerve stimulation is effective in the management of type 2 diabetes. Hence, the present study was undertaken to determine the effectiveness of vestibular nerve stimulation using portable battery-operated vestibular nerve stimulator in the management of diabetes.
The present study was a double-blind randomized controlled trial with 1:1 split between the control and experimental groups. A total of 30 participants with type 2 diabetes were part of the study after obtaining the written informed consent. After recording the baseline values, the vestibular nerve stimulation was administered to the participants in the intervention group for 90 days. Sham stimulation was administered to the control group for 90 days. Outcome measures were recorded after 30 days and after 90 days of the intervention in both the groups.
There was significant decrease in the total body weight, fasting, postprandial blood glucose, glycosylated hemoglobin levels, leptin, very low density lipoproteins levels followed by the intervention. There was significant improvement in both spatial and verbal memory scores. Depression and stress scores and systolic blood pressure decreased and remained in normal limits.
The study results have proven multimodal action of vestibular stimulation. It not only acts on regulation of the glucose metabolism but also can regulate the autonomic activity and improve cognition and relieve stress. This is the interesting finding of our study, which needs detailed further research to support implementation of vestibular nerve stimulation as an adjunctive therapy in the management of diabetes.
使用便携式电池供电的前庭神经刺激器进行前庭神经刺激是一种复杂的非侵入性、安全且易于操作的方法。据推测，前庭神经刺激对 2 型糖尿病的治疗有效。因此，本研究旨在确定使用便携式电池供电的前庭神经刺激器进行前庭神经刺激在糖尿病管理中的有效性。
本研究是一项双盲随机对照试验，对照组和实验组的比例为 1:1。在获得书面知情同意后，共有 30 名 2 型糖尿病患者参与了这项研究。记录基线值后，干预组的参与者接受了 90 天的前庭神经刺激。对照组接受了 90 天的假刺激。在干预后 30 天和 90 天记录两组的结果测量值。
干预后，总体重、空腹血糖、餐后血糖、糖化血红蛋白水平、瘦素、极低密度脂蛋白水平均显著下降。空间和言语记忆评分均显著提高。抑郁和压力评分以及收缩压下降并保持在正常范围内。
研究结果证明了前庭刺激的多模式作用。它不仅作用于葡萄糖代谢的调节，还可以调节自主活动，改善认知和缓解压力。这是我们研究的一个有趣发现，需要进一步详细研究来支持将前庭神经刺激作为糖尿病管理的辅助治疗方法的实施。
