Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin Universitygrid.64924.3d, Changchun, People's Republic of China.
Institute of Cardiovascular Sciences, Peking University, Beijing, People's Republic of China.
Infect Immun. 2022 Feb 17;90(2):e0058421. doi: 10.1128/IAI.00584-21. Epub 2021 Dec 13.
Leptospirosis is a global zoonotic disease with outcomes ranging from subclinical infection to fatal Weil's syndrome. In addition to antibiotics, some immune activators have shown protective effects against leptospirosis. However, the unclear relationship between and cytokines has limited the development of antileptospiral immunomodulators. In this study, the particular role of interleukin-10 (IL-10) in leptospirosis was explored by using IL-10-defective (IL-10) hamsters. After infection, an improved survival rate, reduced leptospiral burden, and alleviation of organ lesions were found in IL-10 hamsters compared with wild-type (WT) hamsters. In addition, the levels of expression of the IL-1β, IL-6, and tumor necrosis factor alpha (TNF-α) genes and the level of nitric oxide (NO) were higher in IL-10 hamsters than in WT hamsters. Our results indicate that IL-10 deficiency protects hamsters from infection.
钩端螺旋体病是一种全球性的人畜共患病，其结局从亚临床感染到致命的韦尔氏综合征不等。除了抗生素，一些免疫激活剂已显示出对钩端螺旋体病的保护作用。然而，细胞因子与 之间的关系不明确，限制了抗钩端螺旋体免疫调节剂的发展。在这项研究中，通过使用白细胞介素-10 缺陷（IL-10）仓鼠来探索白细胞介素-10（IL-10）在钩端螺旋体病中的特殊作用。与野生型（WT）仓鼠相比，在 感染后，IL-10 仓鼠的存活率提高，钩端螺旋体负荷减少，器官损伤减轻。此外，IL-1β、IL-6 和肿瘤坏死因子α（TNF-α）基因的表达水平以及一氧化氮（NO）的水平在 IL-10 仓鼠中高于 WT 仓鼠。我们的结果表明，IL-10 缺乏可保护仓鼠免受 感染。
