Pediatric Oncology Branch, Rare Tumor Initiative, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD 20892, USA.
Curr Oncol. 2021 Nov 1;28(6):4357-4366. doi: 10.3390/curroncol28060370.
Adrenocortical carcinoma (ACC) is a rare malignancy with an overall unfavorable prognosis. Clinicians treating patients with ACC have noted accelerated growth in metastatic liver lesions that requires rapid intervention compared to other metastatic locations. This study measured and compared the growth rates of metastatic ACC lesions in the lungs, liver, and lymph nodes using volumetric segmentation. A total of 12 patients with metastatic ACC (six male; six female) were selected based on their medical history. Computer tomography (CT) exams were retrospectively reviewed and a sampling of ≤5 metastatic lesions per organ were selected for evaluation. Lesions in the liver, lung, and lymph nodes were measured and evaluated by volumetric segmentation. Statistical analyses were performed to compare the volumetric growth rates of the lesions in each organ system. In this cohort, 5/12 had liver lesions, 7/12 had lung lesions, and 5/12 had lymph node lesions. A total of 92 lesions were evaluated and segmented for lesion volumetry. The volume doubling time per organ system was 27 days in the liver, 90 days in the lungs, and 95 days in the lymph nodes. In this series of 12 patients with metastatic ACC, liver lesions showed a faster growth rate than lung or lymph node lesions.
肾上腺皮质癌（ACC）是一种罕见的恶性肿瘤，总体预后不良。治疗 ACC 患者的临床医生注意到转移性肝病变的生长速度加快，与其他转移部位相比需要迅速干预。本研究使用体积分割测量并比较了肺、肝和淋巴结中转移性 ACC 病变的生长速度。根据病史，共选择了 12 名患有转移性 ACC（6 名男性；6 名女性）的患者。回顾性审查计算机断层扫描（CT）检查，并选择每个器官的≤5 个转移性病变进行评估。通过体积分割测量和评估肝、肺和淋巴结中的病变。进行了统计学分析，以比较每个器官系统中病变的体积增长率。在该队列中，5/12 例有肝病变，7/12 例有肺病变，5/12 例有淋巴结病变。共评估和分割了 92 个病变进行病变体积测量。每个器官系统的体积倍增时间分别为肝脏 27 天、肺部 90 天和淋巴结 95 天。在这一系列 12 名转移性 ACC 患者中，肝病变的生长速度比肺或淋巴结病变快。
