Zhong Rui, Chen Qingling, Zhang Xinyue, Li Nan, Lin Weihong
Department of Neurology, First Hospital, Jilin University, Changchun, China.
Department of Hepatology, Tianjin Medical University, Tianjin Second People's Hospital, Tianjin, China.
Front Psychiatry. 2021 Nov 24;12:784737. doi: 10.3389/fpsyt.2021.784737. eCollection 2021.
To investigate whether emerging depressive and anxiety symptoms are predictors of seizure recurrence in a cohort of patients with newly diagnosed epilepsy (PWNDE) who did not have a history of psychiatric diagnosis. A cohort of 283 PWNDE were psychiatrically assessed before antiseizure medication (ASM) therapy and were followed for 12 months to assess seizure recurrence. The influence of depressive and anxiety symptoms score on seizure recurrence was assessed using univariate and multivariate binary logistic regression analysis. Receiver operating characteristic (ROC) curve analysis was utilized. A total of 283 individuals were included in final analysis, and 115 patients (40.6%) experienced seizure recurrence during follow-up. In multivariate logistic regression analysis, NDDI-E and GAD-7 score were associated with an increased risk of seizure recurrence with an adjusted OR of 1.360 (CI: 1.176-1.572; < 0.001) and 1.101 (CI: 1.004-1.209; = 0.041), respectively. Additionally, the adjusted OR and 95% CI of seizure recurrence for the "high NDDI-E score and high GAD-7 score" vs. "not high NDDI-E score and not high GAD-7 score" was 7.059 (3.521-14.149) ( for trend < 0.001). We found that an emergence of new psychiatric symptoms including depressive and anxiety symptoms were predictors of seizure recurrence in adults with newly diagnosed epilepsy who did not have psychiatric history.
为了研究在一组无精神疾病诊断史的新诊断癫痫患者（PWNDE）中，新出现的抑郁和焦虑症状是否是癫痫复发的预测因素。对283名PWNDE患者在开始抗癫痫药物（ASM）治疗前进行精神评估，并随访12个月以评估癫痫复发情况。使用单因素和多因素二元逻辑回归分析评估抑郁和焦虑症状评分对癫痫复发的影响。采用受试者工作特征（ROC）曲线分析。最终分析共纳入283例个体，115例患者（40.6%）在随访期间出现癫痫复发。在多因素逻辑回归分析中，NDDI-E和GAD-7评分与癫痫复发风险增加相关，调整后的比值比分别为1.360（CI：1.176 - 1.572；P < 0.001）和1.101（CI：1.004 - 1.209；P = 0.041）。此外，“高NDDI-E评分和高GAD-7评分”与“非高NDDI-E评分和非高GAD-7评分”相比，癫痫复发的调整后比值比和95%可信区间为7.059（3.521 - 14.149）（趋势P < 0.001）。我们发现，在无精神病史的新诊断癫痫成人中，包括抑郁和焦虑症状在内的新出现的精神症状是癫痫复发的预测因素。
