使用单核苷酸多态性阵列分析胆管癌中的体细胞拷贝数改变
Analysis of somatic copy number alterations in biliary tract carcinoma using a single nucleotide polymorphism array.
作者信息
Shioi Yoshihiro, Osakabe Mitsumasa, Yanagawa Naoki, Nitta Hiroyuki, Sasaki Akira, Sugai Tamotsu
机构信息
Department of Molecular Diagnostic Pathology, School of Medicine, Iwate Medical University, 2-1-1, Shiwagun, Yahabachou, 0283695, Japan.
Department of Surgery, School of Medicine, Iwate Medical University, 2-1-1, Shiwagun, Yahabachou, 0283695, Japan.
出版信息
Future Sci OA. 2021 Nov 15;8(1):FSO766. doi: 10.2144/fsoa-2021-0057. eCollection 2022 Jan.
AIM
Biliary tract carcinoma (BTC), including gall bladder carcinoma (GBC) and biliary duct carcinoma (BDC), has a poor prognosis. Comprehensive genomic profiling has important roles in evaluation of the carcinogenesis of BTC.
MATERIALS & METHODS: We examined somatic copy number alterations (SCNAs) using a single nucleotide polymorphism array system to analyze 36 BTC samples (11 GBCs and 25 BDCs).
RESULTS
In hierarchical cluster analysis, two clusters were identified (subgroup 1 with low SCNAs and subgroup 2 with high SCNAs). GBC was predominant in subgroup 1, whereas BDC was predominant in subgroup 2, suggesting that GBC and BDC had different genetic backgrounds in terms of SCNAs.
CONCLUSION
These findings could be helpful for establishing the molecular carcinogenesis of BTCs.
目的
胆道癌（BTC），包括胆囊癌（GBC）和胆管癌（BDC），预后较差。综合基因组分析在评估BTC的致癌过程中具有重要作用。
材料与方法
我们使用单核苷酸多态性阵列系统检测体细胞拷贝数改变（SCNA），以分析36例BTC样本（11例GBC和25例BDC）。
结果
在层次聚类分析中，识别出两个聚类（SCNA低的亚组1和SCNA高的亚组2）。GBC在亚组1中占主导，而BDC在亚组2中占主导，这表明在SCNA方面GBC和BDC具有不同的遗传背景。
结论
这些发现可能有助于确立BTC的分子致癌机制。
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