Wang Hanyu, Yu Yuxin, Wang Kang, Sun Hui
Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Oncol. 2021 Nov 24;11:769807. doi: 10.3389/fonc.2021.769807. eCollection 2021.
Thyroid cancers are the most common endocrine malignancies with a dramatic increase in incidences. Anaplastic thyroid cancer is a rare but deadly form among thyroid cancers. To better understand of this field, we assessed the global scientific outputs and tried to depict its overview bibliometric methods.
Approximately 1,492 science publications published between 1997 and 2020 were included by systematic retrieval in the WoS database. The general information of them was characterized, and the developmental skeleton and research frontiers were explored.
The article number in this field has been increasing in the past 24 years. North America, East Asia, and Western Europe have reached remarkable achievements. Mutations of and and their downstream pathways have attracted researchers' attention, where genetic diagnosis provides new clinical insight and several targeted therapeutic approaches have been on the clinical trial.
Numerous efforts have been made to figure out gene expression reprogramming of anaplastic thyroid cancer and key mechanism in driving its dedifferentiation, invasion and migration process. Targeted therapy, immunotherapy, and systematic combination therapy are the recent current research hotspots. These results provide insightful clues for the funding direction and the potential breakthrough direction of the anaplastic thyroid cancer study.
甲状腺癌是最常见的内分泌恶性肿瘤，其发病率急剧上升。间变性甲状腺癌是甲状腺癌中一种罕见但致命的类型。为了更好地了解该领域，我们评估了全球科学产出，并尝试用文献计量学方法描绘其概况。
通过系统检索Web of Science数据库，纳入了1997年至2020年间发表的约1492篇科学出版物。对其一般信息进行了表征，并探索了发展脉络和研究前沿。
在过去24年中，该领域的文章数量一直在增加。北美、东亚和西欧取得了显著成就。[此处原文缺失相关基因信息]的突变及其下游途径已引起研究人员的关注，其中基因诊断提供了新的临床见解，并且几种靶向治疗方法已进入临床试验阶段。
人们已经做出了许多努力来弄清楚间变性甲状腺癌的基因表达重编程及其去分化、侵袭和迁移过程中的关键机制。靶向治疗、免疫治疗和系统联合治疗是当前最新的研究热点。这些结果为间变性甲状腺癌研究的资助方向和潜在突破方向提供了有见地的线索。
