Ding Yuanzhe, Zhang Di, Wang Sheng, Zhang Xiaolei, Yang Jingquan
Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
The Second School of Medicine, Wenzhou Medical University, Wenzhou, China.
Front Cell Dev Biol. 2021 Nov 24;9:767888. doi: 10.3389/fcell.2021.767888. eCollection 2021.
Spinal cord injury (SCI) is a devastating disease leading to loss of sensory and motor functions, whose pathological process includes mechanical primary injury and secondary injury. Macrophages play an important role in SCI pathology. According to its origin, it can be divided into resident microglia and peripheral monocyte-derived macrophages (hematogenous Mφ). And it can also be divided into M1-type macrophages and M2-type macrophages on the basis of its functional characteristics. Hematogenous macrophages may contribute to the SCI process through infiltrating, scar forming, phagocytizing debris, and inducing inflammatory response. Although some of the activities of hematogenous macrophages are shown to be beneficial, the role of hematogenous macrophages in SCI remains controversial. In this review, following a brief introduction of hematogenous macrophages, we mainly focus on the function and the controversial role of hematogenous macrophages in SCI, and we propose that hematogenous macrophages may be a new therapeutic target for SCI.
脊髓损伤（SCI）是一种导致感觉和运动功能丧失的毁灭性疾病，其病理过程包括机械性原发性损伤和继发性损伤。巨噬细胞在脊髓损伤病理过程中发挥着重要作用。根据其来源，可分为常驻小胶质细胞和外周单核细胞衍生的巨噬细胞（血源性巨噬细胞）。根据其功能特性，又可分为M1型巨噬细胞和M2型巨噬细胞。血源性巨噬细胞可能通过浸润、瘢痕形成、吞噬碎片和诱导炎症反应来促进脊髓损伤进程。尽管血源性巨噬细胞的某些活动显示出有益作用，但其在脊髓损伤中的作用仍存在争议。在本综述中，在简要介绍血源性巨噬细胞之后，我们主要关注血源性巨噬细胞在脊髓损伤中的功能和争议性作用，并提出血源性巨噬细胞可能是脊髓损伤的一个新的治疗靶点。
