Tahedl Marlene, Li Hi Shing Stacey, Finegan Eoin, Chipika Rangariroyashe H, Lope Jasmin, Murad Aizuri, Hardiman Orla, Bede Peter
Computational Neuroimaging Group, Trinity Biomedical Sciences Institute, Trinity College Dublin, Pearse Street Room 5.43, Dublin, Ireland.
Department of Psychiatry and Psychotherapy and Institute for Psychology, University of Regensburg, Germany.
Data Brief. 2021 Oct 14;39:107484. doi: 10.1016/j.dib.2021.107484. eCollection 2021 Dec.
Imaging profiles from a longitudinal single-centre motor neuron disease study are presented. A standardized T1-weighted MRI protocol was implemented to characterise cortical disease burden trajectories across the UMN (upper motor neuron) - LMN (lower motor neuron) spectrum of motor neuron diseases (MNDs) (Tahedl et al., 2021). Patients with amyotrophic lateral sclerosis (ALS = 61), patients with primary lateral sclerosis (PLS = 23) and poliomyelitis survivors (PMS = 45) were included. Up to four longitudinal scans were available for each patient, separated by an inter-scan-interval of four months. Individual and group-level cortical thickness profiles were appraised using a normalisation procedure with reference to subject-specific control groups. A -scoring approach was utilised, where each patients' cortex was first segmented into 1000 cortical regions, and then rated as 'thin', 'thick', or 'comparable' to the corresponding region of a demographically-matched control cohort. Fractions of significantly 'thin' and 'thick' patches were calculated across the entire cerebral vertex as well as in specific brain regions, such as the motor cortex, parietal, frontal and temporal cortices. This approach allows the characterisation of disease burden in individual subjects as well as at a group-level, both cross-sectionally and longitudinally. The presented framework may aid the interpretation of individual cortical disease burden in other patient cohorts.
本文展示了一项纵向单中心运动神经元疾病研究的成像资料。采用标准化的T1加权MRI方案，以描述运动神经元疾病（MNDs）上运动神经元（UMN）-下运动神经元（LMN）谱系中皮质疾病负担轨迹（塔赫德尔等人，2021年）。纳入了肌萎缩侧索硬化症患者（ALS = 61例）、原发性侧索硬化症患者（PLS = 23例）和小儿麻痹症幸存者（PMS = 45例）。每位患者最多可进行四次纵向扫描，扫描间隔为四个月。使用归一化程序并参照个体特异性对照组评估个体和组水平的皮质厚度资料。采用A评分法，先将每位患者的皮质分割为1000个皮质区域，并与人口统计学匹配的对照队列的相应区域相比，评定为“薄”、“厚”或“相当”。计算整个脑顶点以及特定脑区（如运动皮质、顶叶、额叶和颞叶皮质）中显著“薄”和“厚”斑块的比例。这种方法能够在个体和组水平上，从横断面和纵向对疾病负担进行特征描述。所提出的框架可能有助于解释其他患者队列中的个体皮质疾病负担情况。
