"P2RY8- 子" 耐受破坏促进 SLE。

"P2RY8-son" break of tolerance promotes SLE.

机构信息

Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, Centre National de la Recherche Scientifique, UMR5308, ENS de Lyon, Lyon, France.

National Reference Centre for Rheumatic and AutoImmune and Systemic Diseases in Children (RAISE), Lyon, France.

出版信息

J Exp Med. 2022 Jan 3;219(1). doi: 10.1084/jem.20211972. Epub 2021 Dec 13.

DOI:10.1084/jem.20211972

PMID:34901992

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8672645/

Abstract

In this issue of JEM, He et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20211004) associate novel P2RY8 genetic variants to lupus, expanding the field of monogenic autoimmunity. The authors demonstrate that P2RY8 prevents the expansion of DNA-reactive B cells by restraining B cell mobility and activation within the germinal center.

摘要

在本期的《实验医学杂志》中，He 等人（2021. J. Exp. Med. https://doi.org/10.1084/jem.20211004）将新的 P2RY8 遗传变异与狼疮联系起来，扩展了单基因自身免疫的领域。作者证明，P2RY8 通过限制生发中心内 B 细胞的迁移和激活来防止 DNA 反应性 B 细胞的扩增。