液滴探针质谱法在研究治疗药物生物分布中的开发与应用。
Development and Application of DropletProbe Mass Spectrometry for Examining Biodistribution of Therapeutics.
机构信息
Department of Preclinical Development, Merck & Co., Inc., Kenilworth, NJ, USA.
Bioanalytical Mass Spectrometry Group, Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, USA.
出版信息
Methods Mol Biol. 2022;2437:171-180. doi: 10.1007/978-1-0716-2030-4_12.
dropletProbe mass spectrometry is a novel technique for molecular characterization of surfaces. It can be used for rapid ex vivo analysis of therapeutics from thin animal tissue sections and has been shown to improve understanding of a drug's absorption, distribution, metabolism and excretion (ADME) properties. Here, we describe the tissue distribution analysis of diclofenac from a dosed whole-body mouse thin tissue section using a dropletProbe mass spectrometry system.
液滴探针质谱是一种用于表面分子特征分析的新技术。它可以用于快速对来自薄动物组织切片的治疗药物进行离体分析，并且已经证明它可以提高对药物吸收、分布、代谢和排泄（ADME）性质的理解。在这里，我们使用液滴探针质谱系统描述了全身给药的小鼠薄组织切片中双氯芬酸的组织分布分析。
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