Sochor H, Schelbert H R, Schwaiger M, Henze E, Phelps M E
Eur J Nucl Med. 1986;12 Suppl:S66-9. doi: 10.1007/BF00258110.
Positron emission tomography (PET) permits in vivo as well as noninvasive study of fatty acid metabolism. Parameters of 11C-palmitate kinetics relate to the oxidation of fatty acids, and palmitic acid uptake is impaired in patients with coronary disease and cardiomyopathy. Normal myocardium shows homogeneous fatty acid metabolism and can resort to alternate substrates. Diseased myocardium exhibits regional heterogeneity in fatty acid uptake and utilization. In patients with cardiomyopathy, distinct patterns of fatty acid metabolism can be observed following changes of substrate availability by application of an oral glucose load. This intervention also enhances the heterogeneity of 11C-palmitic acid (CPA) uptake and clearance. Thus, PET studies with CPA permit the noninvasive demonstration of effects on substrate availability and may help to characterize patients with ventricular dysfunction on the biochemical level.
正电子发射断层扫描（PET）可对脂肪酸代谢进行体内无创研究。11C-棕榈酸动力学参数与脂肪酸氧化相关，冠心病和心肌病患者的棕榈酸摄取受损。正常心肌显示出均匀的脂肪酸代谢，并且可以采用替代底物。患病心肌在脂肪酸摄取和利用方面表现出区域异质性。在心肌病患者中，口服葡萄糖负荷改变底物可用性后，可观察到不同的脂肪酸代谢模式。这种干预还增强了11C-棕榈酸（CPA）摄取和清除的异质性。因此，使用CPA的PET研究能够无创地证明对底物可用性的影响，并可能有助于在生化水平上对心室功能障碍患者进行特征描述。
