PHIST：从宏基因组病毒序列中快速准确地预测原核宿主。
PHIST: fast and accurate prediction of prokaryotic hosts from metagenomic viral sequences.
机构信息
Department of Computational Biology, Adam Mickiewicz University, Poznan 61-614, Poland.
Faculty of Automatic Control, Electronics and Computer Science, Silesian University of Technology, Gliwice 44-100, Poland.
出版信息
Bioinformatics. 2022 Feb 7;38(5):1447-1449. doi: 10.1093/bioinformatics/btab837.
SUMMARY
Phage-Host Interaction Search Tool (PHIST) predicts prokaryotic hosts of viruses based on exact matches between viral and host genomes. It improves host prediction accuracy at species level over current alignment-based tools (on average by 3 percentage points) as well as alignment-free and CRISPR-based tools (by 14-20 percentage points). PHIST is also two orders of magnitude faster than alignment-based tools making it suitable for metagenomics studies.
AVAILABILITY AND IMPLEMENTATION
GNU-licensed C++ code wrapped in Python API available at: https://github.com/refresh-bio/phist.
SUPPLEMENTARY INFORMATION
Supplementary data are available at Bioinformatics online.
摘要
噬菌体-宿主相互作用搜索工具（PHIST）基于病毒和宿主基因组之间的精确匹配来预测病毒的原核宿主。与基于比对的现有工具相比，它提高了宿主预测的准确性（平均提高 3 个百分点），也提高了非比对和基于 CRISPR 的工具的准确性（提高 14-20 个百分点）。PHIST 比基于比对的工具快两个数量级，使其适用于宏基因组学研究。
可用性和实现
用 Python API 包装的 GNU 许可的 C++ 代码可在：https://github.com/refresh-bio/phist 获得。
补充信息
补充数据可在生物信息学在线获得。
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