Department of Medicine, Hualien Armed Forces General Hospital, Hualien City 970, Taiwan.
Department of Critical Care Medicine, Taipei Tzu-Chi General Hospital New Taipei City 231, Taiwan.
Cardiovasc Hematol Disord Drug Targets. 2021;21(4):217-224. doi: 10.2174/1871529X21666211214154545.
Severe microcytic anemia has been associated with BP changes.
Whether the erythrocyte indices are associated with long-term BPV is unknown. This study aimed to investigate the association of hemoglobin levels and erythrocyte size with long-term blood pressure variability (BPV) in young males.
This study included 1,112 healthy military males, averaging 32 years of age, in Taiwan. All participants took a measurement of systolic and diastolic BP (SBP and DBP) every two-year from 2012 to 2018 (2012-14, 2014-15, 2015-16, 2016-18). Levels of hemoglobin and mean corpuscular volume (MCV) of erythrocytes were obtained at the first visit. Long-term BPV was assessed by the standard deviation (SD) and average real variability (ARV). Multivariate linear regression analysis with adjustment for the baseline BP levels and other covariates was used to elucidate the association.
Hemoglobin levels were borderline positively correlated with SD DBP (β and standard errors = 0.016 (0.009), P =0.06). In those with hemoglobin levels of 10.0-13.9 g/dL, hemoglobin was negatively correlated with SDSBP (β= -0.039 (0.018), P =0.03). In contrast, MCV levels were borderline positively correlated with SDSBP (β =0.085 (0.052), P =0.09). In those with MCV levels <80 fL, MCV was positively correlated with SDSBP and ARVSBP (β= 0.445 (0.210) and 0.286 (0.149), p = 0.03 and 0.05, respectively).
There were inconsistent patterns for the associations of erythrocyte indices with longterm BPV. We found a U-shaped relationship of hemoglobin levels with systolic BPV, whereas there was a positive linear relationship of hemoglobin and MCV levels with diastolic BPV, respectively.
严重小细胞性贫血与血压变化有关。
红细胞指数是否与长期血压变异性（BPV）有关尚不清楚。本研究旨在探讨血红蛋白水平和红细胞大小与年轻男性长期血压变异性（BPV）的关系。
本研究纳入了台湾 1112 名平均年龄 32 岁的健康军人男性。所有参与者在 2012 年至 2018 年期间每两年测量一次收缩压和舒张压（SBP 和 DBP）（2012-14、2014-15、2015-16、2016-18）。在第一次就诊时获得血红蛋白和红细胞平均体积（MCV）水平。通过标准差（SD）和平均真实变异性（ARV）评估长期 BPV。采用多元线性回归分析，调整基线 BP 水平和其他协变量，以阐明相关性。
血红蛋白水平与 SDDBP 呈临界正相关（β和标准误差=0.016（0.009），P=0.06）。在血红蛋白水平为 10.0-13.9 g/dL 的人群中，血红蛋白与 SDSBP 呈负相关（β= -0.039（0.018），P=0.03）。相反，MCV 水平与 SDSBP 呈临界正相关（β=0.085（0.052），P=0.09）。在 MCV 水平<80 fL 的人群中，MCV 与 SDSBP 和 ARVSBP 呈正相关（β=0.445（0.210）和 0.286（0.149），p=0.03 和 0.05）。
红细胞指数与长期 BPV 的关联模式不一致。我们发现血红蛋白水平与收缩压变异性呈 U 型关系，而血红蛋白和 MCV 水平与舒张压变异性呈正线性关系。
