Department of Cardiovascular Medicine, School of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
Department of Internal Medicine, Tri-Service General Hospital and National Defense Medical Center, Taipei 114, Taiwan.
Int J Environ Res Public Health. 2020 Aug 21;17(17):6094. doi: 10.3390/ijerph17176094.
: An inverse relationship of serum liver transaminases and mortality might be due to better blood pressure control in hypertensive patients. Whether it holds true regarding such an association for long-term blood pressure variability (BPV) in those without antihypertensive therapy is unclear. : A population of 1112 military males without antihypertensive medications, aged 32 years, was collected from a retrospective longitudinal study in Taiwan. Serum liver aspartate and alanine transaminase (AST and ALT) levels were obtained from a 12 h-fast blood sample of each participant. BPV was assessed by standard deviation (SD) and average real variability (ARV) of systolic and diastolic blood pressure (SBP and DBP), respectively across 4 visits during the study period (2012-2014, 2014-2015, 2015-2016, and 2016-2018). Multivariable linear regression analysis was utilized to determine the association adjusting for demographics, anthropometric indexes, SBP, DBP, and lipid profiles. : In the unadjusted model, ALT was significantly and positively correlated with SD and ARV (β (standard errors) = 0.36 (0.16) and 0.24 (0.12), respectively), and so was AST (β = 0.19 (0.08) and 0.14 (0.06), respectively). All the associations were insignificant with adjustments. However, ALT was significantly and negatively correlated with SD and ARV (β = -0.35 (0.14) and -0.25 (0.11), respectively) and so was AST (β = -0.14 (0.07) and -0.12 (0.06), respectively) with adjustments. : Our findings suggested that serum liver transaminases were negatively correlated with long-term systolic BPV in young male adults without antihypertensive therapy, and the clinical relevance needs further investigations.
血清肝转氨酶与死亡率呈负相关，这可能是由于高血压患者的血压控制更好。但是，对于未经降压治疗的患者，这种关联是否适用于长期血压变异性（BPV）尚不清楚。
我们从台湾的一项回顾性纵向研究中收集了 1112 名年龄在 32 岁的无抗高血压药物的男性军人。从每位参与者的 12 小时禁食血液样本中获得血清天门冬氨酸和丙氨酸转氨酶（AST 和 ALT）水平。通过标准偏差（SD）和收缩压和舒张压（SBP 和 DBP）的平均真实变异性（ARV）分别评估 BPV，这是在研究期间（2012-2014、2014-2015、2015-2016 和 2016-2018 年）的 4 次访视中获得的。使用多变量线性回归分析来确定调整人口统计学，人体测量指标，SBP，DBP 和血脂谱后的关联。
在未调整的模型中，ALT 与 SD 和 ARV 呈显著正相关（β（标准误差）= 0.36（0.16）和 0.24（0.12）），AST 也是如此（β= 0.19（0.08）和 0.14（0.06））。所有关联在调整后均无统计学意义。但是，ALT 与 SD 和 ARV 呈显著负相关（β=-0.35（0.14）和-0.25（0.11）），AST 也是如此（β=-0.14（0.07）和-0.12（0.06）），调整后。
我们的发现表明，在未经抗高血压治疗的年轻男性成年人中，血清肝转氨酶与长期收缩压 BPV 呈负相关，其临床相关性需要进一步研究。
