Bader Doaa, Adam Ahmed, Shaban Mohamed, Alyahya Bader
Royal Commission Medical Center, Yanbu, 46451, Saudi Arabia.
Emergency Medicine Department, King Saud University Medical City, King Saud University, Box 2925, Riyadh, PO, 11461, Saudi Arabia.
Int J Emerg Med. 2021 Dec 14;14(1):73. doi: 10.1186/s12245-021-00397-y.
Tizanidine, an α-2 adrenoceptor agonist, is widely prescribed for the management of spasticity in adults. Case reports on pediatric tizanidine overdose are limited. Here, we report a case of pediatric tizanidine toxicity that was reversed with naloxone.
A 3-year-old male presented to the emergency department with lethargy, bradycardia, and bradypnea after accidental ingestion of multiple tizanidine tablets. Improvements in the level of consciousness and respiratory and heart rates were observed after two intravenous administrations of naloxone at a dose of 0.05 and 0.1 mg/kg, respectively.
This case report provides further evidence regarding the use of naloxone as a viable antidote for centrally acting α-2 receptor agonists and presents additional epidemiologic data on childhood tizanidine poisoning.
替扎尼定是一种α-2肾上腺素能受体激动剂，广泛用于治疗成人痉挛。关于儿童替扎尼定过量的病例报告有限。在此，我们报告一例用纳洛酮逆转的儿童替扎尼定中毒病例。
一名3岁男性在意外摄入多片替扎尼定片后出现嗜睡、心动过缓和呼吸过缓，被送往急诊科。分别静脉注射两次剂量为0.05和0.1 mg/kg的纳洛酮后，意识水平、呼吸和心率均有改善。
本病例报告提供了关于使用纳洛酮作为中枢作用α-2受体激动剂的有效解毒剂的进一步证据，并提供了关于儿童替扎尼定中毒的额外流行病学数据。
