Sinha Y, Cranswick N E
Department of Clinical Pharmacology, Royal Children's Hospital, Melbourne, Victoria, Australia.
J Paediatr Child Health. 2004 Dec;40(12):678-80. doi: 10.1111/j.1440-1754.2004.00491.x.
To identify cases of clonidine poisoning presenting to a tertiary paediatric hospital and to investigate trends in presentation, outcome and prevention. Furthermore, any public health implications of the use of clonidine in children are to be explored.
Cases of clonidine poisoning presenting to Royal Children's Hospital were reviewed over the period from 1997 to 2001 (inclusive), with significant data obtained from coded medical records.
Twenty-four cases of clonidine poisoning were identified over the 5-year period. Nine patients ingested their own medication, which was prescribed for attention-deficit hyperactivity disorder. Clonidine was prescribed for a child in 16 cases (67%). Impaired conscious state and bradycardia were the most common presenting features. Activated charcoal was given in 14 cases and volume expansion in six. There were 12 children (50%) who required admission to intensive care for monitoring, including three who received mechanical ventilation. The average length of stay was 25.7 h with no long-term complications.
This is the largest series of clonidine poisoning in children recorded in Australia, with morbidity considerable. Emphasis needs to be placed on educating parents of clonidine's dangers in overdose to their own children as well as others.
确定在一家三级儿科医院就诊的可乐定中毒病例，并调查其就诊情况、结局及预防趋势。此外，还将探讨儿童使用可乐定对公共卫生的影响。
回顾了1997年至2001年（含）期间在皇家儿童医院就诊的可乐定中毒病例，并从编码的病历中获取了重要数据。
在这5年期间共确定了24例可乐定中毒病例。9名患者误服了自己用于治疗注意力缺陷多动障碍的药物。16例（67%）中可乐定是给儿童开的药。意识状态受损和心动过缓是最常见的就诊表现。14例给予了活性炭，6例给予了扩容治疗。12名儿童（50%）需要入住重症监护室进行监测，其中3例接受了机械通气。平均住院时间为25.7小时，无长期并发症。
这是澳大利亚记录的最大系列儿童可乐定中毒病例，发病率较高。需要重点教育家长了解可乐定过量对自己孩子以及其他孩子的危害。
