Human urinary epidermal growth factor: effects of age, sex and female endocrine status.

Urinary concentrations of immunoreactive epidermal growth factor (irEGF) were determined by specific homologous radioimmunoassay in 300 healthy women and 163 healthy men between 16 and 93 years of age. Both absolute (ng/ml) and relative (ng/mg creatinine) concentrations decreased with age in both sexes. The relative concentration was higher in women than in men at ages 20-70 years (P less than 0.001), the respective mean values (ng/mg creatinine) being 49.1 and 40.1 at 16-20 years, 58.9 and 41.8 at 20-30 years, 47.6 and 36.9 at 30-45 years, 42.8 and 29.0 at 45-55 years, 44.9 and 30.1 at 55-70 years, and 16.0 and 18.5 in those over 70 years. The values were unaffected by the menstrual cycle, pregnancy, oral contraceptives, or postmenopausal estrogen and/or progestin therapy.