各种人类恶性肿瘤中的尿表皮生长因子浓度。
Urinary epidermal growth factor concentrations in various human malignancies.
作者信息
Mattila A L, Saario I, Viinikka L, Ylikorkala O, Perheentupa J
机构信息
Children's Hospital, Helsinki, Finland.
出版信息
Br J Cancer. 1988 Feb;57(2):139-41. doi: 10.1038/bjc.1988.29.
Abstract
We determined the concentrations of immunoreactive epidermal growth factor in the urine (U-irEGF) of 97 adult patients with various malignancies, including carcinomas of the urinary bladder, kidney, stomach, colon, rectum, breast, endometrium, uterine cervix, ovary, vagina, prostate, pancreas and thyroid, liposarcoma and skin melanoma. The relative U-irEGF concentrations (ng m-1 creatinine) were higher (P = 0.002) for the whole series of female patients than for healthy controls matched for sex and age. Such difference did not appear for male patients. The only specific group with a statistically supranormal U-irEGF concentration (P = 0.0005) comprised women with endometrial carcinoma of the uterus.
摘要
我们测定了97例患有各种恶性肿瘤的成年患者尿液中免疫反应性表皮生长因子（U-irEGF）的浓度，这些患者包括膀胱癌、肾癌、胃癌、结肠癌、直肠癌、乳腺癌、子宫内膜癌、宫颈癌、卵巢癌、阴道癌、前列腺癌、胰腺癌和甲状腺癌患者，以及脂肪肉瘤和皮肤黑色素瘤患者。整个女性患者系列的U-irEGF相对浓度（ng m-1肌酐）高于年龄和性别匹配的健康对照组（P = 0.002）。男性患者未出现这种差异。唯一U-irEGF浓度具有统计学超常水平（P = 0.0005）的特定组是患有子宫内膜癌的女性。
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