Emerg Infect Dis. 2022 Feb;28(2):323-330. doi: 10.3201/eid2802.210945. Epub 2021 Dec 14.
During March 2016-January 2019, Burkholderia cepacia complex (BCC) infection developed in 13 persons who inject drugs (PWID) in Kowloon West Region, Hong Kong, China. Seven cases were infective spondylitis, 2 endocarditis, 2 septic arthritis, 1 intramuscular abscess and bacteremia, and 1 necrotizing fasciitis. Pulsed-field gel electrophoresis revealed that the isolates from 9 patients were clonally related. This clone caused major illness, and 11 of the 13 patients required surgical treatment. Clinicians should be aware of this pathogen and the appropriate broad-spectrum antimicrobial drugs to empirically prescribe for PWID with this life-threatening infection. Close collaboration among public health authorities, outreach social workers, and methadone clinics is essential for timely prevention and control of outbreaks in the PWID population.
2016 年 3 月至 2019 年 1 月期间，中国香港九龙西区 13 名吸毒者（PWID）感染了洋葱伯克霍尔德菌复合群（BCC）。7 例为感染性脊椎炎，2 例心内膜炎，2 例化脓性关节炎，1 例肌内脓肿和菌血症，1 例坏死性筋膜炎。脉冲场凝胶电泳显示，9 名患者的分离株具有克隆相关性。该克隆引起了主要疾病，13 名患者中有 11 名需要手术治疗。临床医生应意识到这种病原体以及适当的广谱抗菌药物，以经验性地治疗有生命威胁的感染的 PWID。公共卫生当局、外展社会工作者和美沙酮诊所之间的密切合作，对于 PWID 人群中及时预防和控制疫情至关重要。
