Emerg Infect Dis. 2020 Sep;26(9):1987-1997. doi: 10.3201/eid2609.191746.
Whether Burkholderia cepacia complex should be an objectionable organism in antiseptic solutions with acceptable total bacterial counts is controversial. By using next-generation sequencing, we documented a polyclonal B. cepacia complex outbreak affecting peritoneal dialysis patients in Hong Kong that was caused by contaminated chlorhexidine solutions. Epidemiologic investigations at a manufacturing site identified a semiautomated packaging machine as the probable source of contamination in some of the brands. Use of whole-genome sequencing differentiated the isolates into 3 brand-specific clonal types. Changes in exit site care recommendations, rapid recall of affected products, and tightening of regulatory control for chlorhexidine-containing skin antiseptics could prevent future similar outbreaks. Environmental opportunistic pathogens, including B. cepacia complex, might be included in regular surveillance as indicator organisms for monitoring environmental contamination.
多黏菌素 B 复合物是否应成为可接受总细菌计数的消毒剂溶液中的有害生物体存在争议。通过使用下一代测序，我们记录了一起多克隆洋葱伯克霍尔德菌复合群暴发，影响香港的腹膜透析患者，原因是污染的洗必泰溶液。在制造现场的流行病学调查确定半自动包装机是一些品牌污染的可能来源。全基因组测序将分离株分为 3 种特定品牌的克隆类型。改变出口部位护理建议、迅速召回受影响产品以及加强对含洗必泰皮肤消毒剂的监管控制，可以防止未来发生类似的暴发。环境机会性病原体，包括洋葱伯克霍尔德菌复合群，可能被包括在常规监测中，作为监测环境污染的指示生物。
