定量原位杂交组织化学显示，大鼠肾上腺切除术后促肾上腺皮质激素释放因子mRNA水平升高。
Quantitative in situ hybridization histochemistry reveals increased levels of corticotropin-releasing factor mRNA after adrenalectomy in rats.
作者信息
Young W S, Mezey E, Siegel R E
出版信息
Neurosci Lett. 1986 Oct 8;70(2):198-203. doi: 10.1016/0304-3940(86)90463-5.
PMID:3490635
Abstract
A 35S-labeled 48-base synthetic oligonucleotide complementary to a portion of the rat corticotropin-releasing factor (CRF) mRNA was used for in situ hybridization histochemistry. CRF-synthesizing cells were located in the paraventricular nucleus of the hypothalamus. These cells were observed in the medial parvocellular subdivision where there was a 90% increase in the amount of CRF mRNA per unit volume after adrenalectomy.
摘要
用一个与大鼠促肾上腺皮质激素释放因子（CRF）mRNA的一部分互补的35S标记的48碱基合成寡核苷酸进行原位杂交组织化学。合成CRF的细胞位于下丘脑室旁核。这些细胞见于内侧小细胞亚群，肾上腺切除术后该亚群单位体积内CRF mRNA的量增加了90%。
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