Rao N A, Bowe B E, Sevanian A, Till G O, Marak G E
Ophthalmic Res. 1986;18(4):193-8. doi: 10.1159/000265433.
Experimental lens-induced uveitis was produced in Lewis rats by sensitization with bovine lens protein prior to disruption of the lens capsule. Treatment of these animals by intraperitoneal injection of dimethyl sulfoxide resulted in reduction in retinal vasculitis, hemorrhage and necrosis. Furthermore, morphometric analysis of choroidal inflammation revealed significant reduction of choroidal thickness in the treated animals. These findings suggest that hydroxyl radicals play a role in producing ocular tissue damage in the acute Arthus-type of ocular inflammation.
在破坏晶状体囊之前，通过用牛晶状体蛋白致敏，在Lewis大鼠中诱发实验性晶状体诱导性葡萄膜炎。通过腹腔注射二甲基亚砜对这些动物进行治疗，导致视网膜血管炎、出血和坏死减少。此外，脉络膜炎症的形态计量学分析显示，治疗组动物的脉络膜厚度显著降低。这些发现表明，羟基自由基在急性阿瑟斯型眼部炎症中产生眼组织损伤方面起作用。
