谷胱甘肽过氧化物酶对实验性晶状体诱导性葡萄膜炎的抗炎作用。

Anti-inflammatory effect of glutathione peroxidase on experimental lens-induced uveitis.

作者信息

Rao N A, Romero J L, Sevanian A, Fernandez M A, Wong C, Ward P A, Marak G E

机构信息

Estelle Doheny Eye Foundation, University of Southern California, Los Angeles.

出版信息

Ophthalmic Res. 1988;20(4):213-9. doi: 10.1159/000266645.

DOI:10.1159/000266645

PMID:3263601

Abstract

An acute lens-induced necrotizing intraocular inflammation was produced in Lewis rats. Treatment of these animals by intraperitoneal injection of glutathione peroxidase resulted in marked decrease in uveal inflammation, retinal edema, hemorrhage and vasculitis. Intraperitoneal injection of glutathione peroxidase resulted in increased levels of this enzyme in ocular tissue. These findings suggest that glutathione peroxidase can modulate acute lens-induced ocular inflammation by serving as a potent anti-inflammatory agent.

摘要

在Lewis大鼠中诱发了急性晶状体诱导的坏死性眼内炎症。通过腹腔注射谷胱甘肽过氧化物酶对这些动物进行治疗，导致葡萄膜炎症、视网膜水肿、出血和血管炎显著减轻。腹腔注射谷胱甘肽过氧化物酶导致眼组织中该酶水平升高。这些发现表明，谷胱甘肽过氧化物酶可作为一种有效的抗炎剂来调节急性晶状体诱导的眼部炎症。