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氨基酸及其药物应用:综述

Amino acids and its pharmaceutical applications: A mini review.

机构信息

Unidad de Investigación y Desarrollo en Tecnología Farmacéutica, UNITEFA-CONICET, Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Cordoba X5000HUA, Argentina.

出版信息

Int J Pharm. 2022 Feb 5;613:121375. doi: 10.1016/j.ijpharm.2021.121375. Epub 2021 Dec 11.

Abstract

Amino acids are natural compounds that can be safely used in pharmaceutical applications. Considering the great interest in the amino acids used in the pharmaceutical industry, this article presents an overview of investigations reported in recent years. In this regard, the first sections begin with an introductory description of the properties, classification and safety of amino acids, while in the other sections the most common methods for the preparation of amino acids formulations and their application on solubilization, permeation and stabilization of several active pharmaceutical ingredients are described. Furthermore, available data about the multicomponent systems approach is included. Lastly, the impact of amino acids formulations on therapeutic efficacy is explored. The advantages illustrated suggest that amino acids are capable of improving the biopharmaceutical properties of drugs.

摘要

氨基酸是可安全用于制药应用的天然化合物。鉴于人们对制药行业中使用的氨基酸非常感兴趣,本文对近年来的研究调查进行了概述。在这方面,前几节首先对氨基酸的性质、分类和安全性进行了介绍性描述,而在其他几节中则描述了制备氨基酸制剂的最常见方法及其在增溶、渗透和稳定几种活性药物成分方面的应用。此外,还包括有关多组分系统方法的现有数据。最后,探讨了氨基酸制剂对治疗效果的影响。所说明的优点表明,氨基酸能够改善药物的生物制药特性。

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