Engelbrecht F M, Mattheyse F J
S Afr Med J. 1986 Oct 11;70(8):483-6.
The beneficial effects of adenosine triphosphate (ATP)-MgCl2 administered as a bolus following fluid infusion or in combination with the infusion fluid were investigated in rabbits subjected to severe but reversible haemorrhagic shock. ATP-MgCl2 treatment led to a significant improvement of the metabolic functions of lung and liver tissue. Kidney tissue showed the same tendency, but the improvement did not reach significant levels. The release of lysosomal enzymes in vivo was retarded after treatment but not stopped. The mean arterial pressure was kept at a relatively constant level when ATP-MgCl2 was infused slowly. Administration as a bolus resulted in an immediate dramatic drop in pressure, followed by recovery and then a gradual decrease to levels which appeared to be incompatible with survival.
在遭受严重但可逆性失血性休克的家兔中，研究了在输液后推注或与输液液联合使用三磷酸腺苷（ATP）-氯化镁的有益效果。ATP-氯化镁治疗使肺和肝组织的代谢功能得到显著改善。肾组织也呈现相同趋势，但改善未达到显著水平。治疗后体内溶酶体酶的释放受到抑制，但未停止。缓慢输注ATP-氯化镁时，平均动脉压保持在相对恒定的水平。推注给药导致血压立即急剧下降，随后恢复，然后逐渐降至似乎与存活不相容的水平。
