GD2 合酶（GD2S）能否在乳腺癌血样中检测到癌症干细胞？
Does GD2 synthase (GD2S) detect cancer stem cells in blood samples of breast carcinomas?
机构信息
Iran University of Medical Sciences, Oncopathology Research Center, Tehran, Iran.
Iran University of Medical Sciences, Faculty of Advanced Technologies in Medicine, Department of Molecular Medicine, Tehran, Iran.
出版信息
J Appl Biomed. 2021 Dec;19(4):181-189. doi: 10.32725/jab.2021.019. Epub 2021 Sep 16.
INTRODUCTION
Cancer stem cells (CSCs) are a theorized subset of cells within the tumor that is thought to drive disease recurrence and metastatic spread. The aim of this study is to investigate mRNA and protein levels of ganglioside GD2 synthase (GD2S), in breast cancer (BC) patients.
METHODS
65 PBMCs of preoperative BC patients without chemotherapy were compared to PBMCs after chemotherapy and controls.
RESULTS
GD2S were significantly higher in BC patients after chemotherapy compared to pre-chemotherapy at both mRNA and protein. GD2S was higher in pre-chemotherapy blood samples compared to control samples.
CONCLUSIONS
Higher expression of GD2S in BC samples compared to healthy control indicates the potential utility of GD2S as a marker of malignancy.
简介
癌症干细胞（CSCs）是肿瘤内的一个理论上的细胞亚群，被认为是导致疾病复发和转移扩散的原因。本研究旨在探讨 GD2 合成酶（GD2S）在乳腺癌（BC）患者中的 mRNA 和蛋白水平。
方法
将 65 例术前未接受化疗的 BC 患者的 PBMC 与化疗后的 PBMC 和对照组进行比较。
结果
与化疗前相比，化疗后的 BC 患者的 GD2S 在 mRNA 和蛋白水平上均显著升高。化疗前的血液样本中的 GD2S 水平高于对照组。
结论
BC 样本中 GD2S 的表达高于健康对照表明 GD2S 作为恶性肿瘤标志物的潜在效用。
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