Keighobadi Masoud, Karimi Narges
Toxoplasmosis Research Center, Communicable Diseases Research Institutes, Mazandaran University of Medical Sciences, Sari, Iran.
School of Medicine, Immunogenetics Research Center, Clinical Research Development Unit of Bou Ali Sina Hospital, Mazandaran University of Medical Sciences, Sari, Iran.
Clin Neuropsychiatry. 2020 Oct;17(5):314-316. doi: 10.36131/cnfioritieditore20200507.
Zolpidem is an imidazopyridine derivative and a non-benzodiazepine hypnotic drug. There are several case reports of zolpidem abuse or dependence and zolpidem withdrawal. This study reports a case of paroxysmal tonic spasm (PTS) after abrupt withdrawal of high dose zolpidem. The case was a 21-year- old male patient with complaints of acute involuntary and painful spasms of all extremities after the sudden withdrawal of taking supratherapeutic zolpidem. In his medical records, He had the history of insomnia and psychiatric disorder . The patient's symptoms improved with intravenous injection of 10 mg diazepam slowly and zolpidem was tapered gradually. This case report indicates that zolpidem has a dependency and abusage properties. To the best of our knowledge , this is the first report of zolpidem withdrawal with PTS.
唑吡坦是一种咪唑并吡啶衍生物，属于非苯二氮䓬类催眠药物。有几例关于唑吡坦滥用、依赖及戒断反应的病例报告。本研究报告了一例高剂量唑吡坦突然停药后出现阵发性强直性痉挛（PTS）的病例。该病例为一名21岁男性患者，在超治疗剂量服用唑吡坦后突然停药，出现四肢急性非自主且疼痛性痉挛。在其病历中，他有失眠和精神疾病史。静脉缓慢注射10mg地西泮后患者症状改善，唑吡坦剂量逐渐减少。本病例报告表明唑吡坦具有依赖性和滥用倾向。据我们所知，这是首例关于唑吡坦戒断引发PTS的报告。
