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Effect of chemical deglycosylation on the in vivo fate of ricin A-chain.

作者信息

Blakey D C, Thorpe P E

出版信息

Cancer Drug Deliv. 1986 Summer;3(3):189-96. doi: 10.1089/cdd.1986.3.189.

DOI:10.1089/cdd.1986.3.189
PMID:3490901
Abstract

Chemical deglycosylation of ricin A-chain virtually eliminated its entrapment by the liver and delayed its clearance from the bloodstream of mice. Liver entrapment of native ricin A-chain occurred to approximately equal extents in the parenchymal and non-parenchymal cell fractions of the liver. The chemical deglycosylation procedure reduced uptake of the A-chain by both cell fractions.

摘要

相似文献

1
Effect of chemical deglycosylation on the in vivo fate of ricin A-chain.
Cancer Drug Deliv. 1986 Summer;3(3):189-96. doi: 10.1089/cdd.1986.3.189.
2
Pharmacokinetics of tumor-reactive immunotoxins in tumor-bearing mice: effect of antibody valency and deglycosylation of the ricin A chain on clearance and tumor localization.荷瘤小鼠体内肿瘤反应性免疫毒素的药代动力学：抗体价态和蓖麻毒素A链去糖基化对清除率和肿瘤定位的影响
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3
Effect of chemical deglycosylation of ricin A chain on the in vivo fate and cytotoxic activity of an immunotoxin composed of ricin A chain and anti-Thy 1.1 antibody.蓖麻毒素A链化学去糖基化对由蓖麻毒素A链和抗Thy 1.1抗体组成的免疫毒素体内命运及细胞毒性活性的影响。
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4
Uptake of native and deglycosylated ricin A-chain immunotoxins by mouse liver parenchymal and non-parenchymal cells in vitro and in vivo.天然及去糖基化蓖麻毒素A链免疫毒素在体外和体内被小鼠肝脏实质细胞和非实质细胞摄取的情况。
Biochim Biophys Acta. 1988 Feb 22;968(2):172-8. doi: 10.1016/0167-4889(88)90005-5.
5
Study of the plasma clearance of antibody--ricin-A-chain immunotoxins. Evidence for specific recognition sites on the A chain that mediate rapid clearance of the immunotoxin.抗体-蓖麻毒素A链免疫毒素的血浆清除研究。A链上介导免疫毒素快速清除的特异性识别位点的证据。
Eur J Biochem. 1986 Feb 17;155(1):1-10. doi: 10.1111/j.1432-1033.1986.tb09451.x.
6
Selective uptake of ricin A-chain by hepatic non-parenchymal cells in vitro. Importance of mannose oligosaccharides in the toxin.体外肝脏非实质细胞对蓖麻毒素A链的选择性摄取。甘露糖寡糖在毒素中的重要性。
FEBS Lett. 1986 Feb 17;196(2):344-8. doi: 10.1016/0014-5793(86)80276-9.
7
The preparation of deglycosylated ricin by recombination of glycosidase-treated A- and B-chains: effects of deglycosylation on toxicity and in vivo distribution.
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8
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9
Modification of the carbohydrate in ricin with metaperiodate-cyanoborohydride mixtures. Effects on toxicity and in vivo distribution.用偏高碘酸盐-氰基硼氢化物混合物对蓖麻毒素中的碳水化合物进行修饰。对毒性和体内分布的影响。
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10
In vivo therapy of the BCL1 tumor: effect of immunotoxin valency and deglycosylation of the ricin A chain.BCL1肿瘤的体内治疗：免疫毒素价态及蓖麻毒素A链去糖基化的影响
Cancer Res. 1988 May 1;48(9):2626-31.

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Pharmacokinetic studies in mice with ICI D0490, a novel recombinant ricin A-chain immunotoxin.使用新型重组蓖麻毒素A链免疫毒素ICI D0490对小鼠进行的药代动力学研究。
Br J Cancer. 1993 Jun;67(6):1310-5. doi: 10.1038/bjc.1993.243.
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