Parra R, Arnau E, Julia A, Lopez A, Nadal A, Allende E
Cancer. 1986 Dec 15;58(12):2717-9. doi: 10.1002/1097-0142(19861215)58:12<2717::aid-cncr2820581227>3.0.co;2-q.
A young woman with acute myelocytic leukemia developed acute lower gastrointestinal bleeding immediately after a first remission induction of her leukemia. After the site of bleeding was located in the descending colon, a necrotic bleeding ulcer was resected. Histologic examination of the ulcer established the diagnosis of gastrointestinal mucormycosis. Treatment with amphotericin B was administered because of the high risk of dissemination. The patient has been followed for 9 months with no evidence of relapse of infection. Survival after gastrointestinal mucormycosis in acute leukemia has not previously been reported in the English language literature. Success in managing mucormycosis depends on the adherence to the recommended principles of early aggressive diagnostic measures, excisional surgery, amphotericin B therapy, and control of the underlying predisposing condition.
一名患有急性髓细胞白血病的年轻女性在首次诱导白血病缓解后立即出现急性下消化道出血。出血部位确定在降结肠后，切除了一个坏死性出血溃疡。对溃疡进行组织学检查确诊为胃肠道毛霉菌病。由于播散风险高，给予两性霉素B治疗。该患者已随访9个月，无感染复发迹象。英文文献中此前尚未报道过急性白血病患者发生胃肠道毛霉菌病后的生存情况。成功治疗毛霉菌病取决于坚持早期积极诊断措施、切除手术、两性霉素B治疗以及控制潜在易感因素等推荐原则。
