Department of Internal Medicine, Division of Cardiology, University Hospitals of Geneva, Switzerland.
Department of Health and Community Medicine, University Hospitals of Geneva, Switzerland.
Swiss Med Wkly. 2021 Dec 13;151:w30093. doi: 10.4414/smw.2021.w30093. eCollection 2021 Dec 6.
Patients surviving COVID-19 have been described as being at risk of developing sequelae. We aimed to investigate and elicit persistent symptoms, emotional status and quality-of-life in patients discharged after an acute COVID-19 episode.
Patient-reported outcome measures were collected during a telephone interview 30 days and 1 year after discharge. Patients' general health status was evaluated using questions based on their symptoms, emotional status was assessed using the items 9 to 12 of the HeartQoL questionnaire and quality of life was assessed at 1 year through the EQ-5D-5L. In patients with a history of cardiovascular disease, all 14 items of the HeartQoL questionnaire were completed to derive the HeartQoL global score.
Among 687 patients who survived after being hospitalised for COVID-19 at the University Hospitals of Geneva between 26 February and 26 April 2020, 184 (27%) and 165 (24%), respectively, participated in the follow-up at 30 days and 1 year. Of these 184 participants, 62% were male, median age was 58 years and 21% had a past medical history of cardiovascular disease. At one month after discharge, 61% (113/184) of patients presented fatigue and 28% (52/184) dyspnoea. One year after discharge, the main complaints were persistent fatigue in 27% (45/165) of patients, neurological problems in 17% (28/165) and dyspnoea in 14% (23/165). Eight percent (14/184) of patients declared being significantly worried 1 month after discharge and 5% (9/184) feeling depressed. The number of patients reporting being significantly worried or depressed at 1 year was lower. Regarding the quality of life at 1 year, the median EQ-5D-5L visual analogue scale score was 80 (interquartile range 70-90).
Approximately half of patients reported some symptoms 1 year after discharge following an acute episode of COVID-19. The predominant symptom was persistent fatigue both at 1-month and at 1-year follow-up. Emotional status and quality of life appeared satisfactory.
有研究描述 COVID-19 幸存者存在发生后遗症的风险。本研究旨在调查和评估急性 COVID-19 后出院患者的持续症状、情绪状态和生活质量。
通过电话访谈，在出院后 30 天和 1 年时收集患者报告的结局测量指标。采用基于症状的问题评估患者的整体健康状况，使用 HeartQoL 问卷的项目 9 至 12 评估情绪状态，使用 EQ-5D-5L 在 1 年时评估生活质量。对于有心血管疾病病史的患者，完成 HeartQoL 问卷的所有 14 个项目，以得出 HeartQoL 总体评分。
2020 年 2 月 26 日至 4 月 26 日期间，在日内瓦大学附属医院因 COVID-19 住院的 687 例患者中，分别有 184 例（27%）和 165 例（24%）在 30 天和 1 年时参与了随访。在这 184 名参与者中，62%为男性，中位年龄为 58 岁，21%有心血管疾病既往史。出院后 1 个月时，61%（113/184）的患者出现疲劳，28%（52/184）的患者出现呼吸困难。出院 1 年后，主要的抱怨是 27%（45/165）的患者持续疲劳，17%（28/165）的患者有神经系统问题，14%（23/165）的患者有呼吸困难。出院后 1 个月，8%（14/184）的患者表示非常担忧，5%（9/184）的患者感到抑郁。在 1 年时报告有明显担忧或抑郁的患者人数较少。关于 1 年时的生活质量，EQ-5D-5L 视觉模拟量表的中位数评分为 80（四分位距 70-90）。
大约一半的患者在急性 COVID-19 后出院 1 年后报告存在一些症状。最主要的症状是持续疲劳，在 1 个月和 1 年随访时均如此。情绪状态和生活质量似乎令人满意。
