新冠病毒感染康复者出院后的健康相关生活质量：一项多中心随访研究。
Health-related quality of life of COVID-19 patients after discharge: A multicenter follow-up study.
作者信息
Qu Guangbo, Zhen Qi, Wang Wenjun, Fan Song, Wu Qibing, Zhang Chengyuan, Li Bao, Liu Gang, Yu Yafen, Li Yonghuai, Yong Liang, Lu Baojing, Ding Zhen, Ge Huiyao, Mao Yiwen, Chen Weiwei, Xu Qiongqiong, Zhang Ruixue, Cao Lu, Chen Shirui, Li Haiwen, Zhang Hui, Hu Xia, Zhang Jing, Wang Yonglian, Zhang Hong, Liang Chaozhao, Sun Liangdan, Sun Yehuan
机构信息
Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, China.
Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, China.
出版信息
J Clin Nurs. 2021 Jun;30(11-12):1742-1750. doi: 10.1111/jocn.15733. Epub 2021 Mar 17.
AIMS AND OBJECTIVES
To determine the health-related quality of life (HRQoL) of COVID-19 patients after discharge and its predicting factors.
BACKGROUND
COVID-19 has caused a worldwide pandemic and led a huge impact on the health of human and daily life. It has been demonstrated that physical and psychological conditions of hospitalised COVID-19 patients are impaired, but the studies focus on physical and psychological conditions of COVID-19 patients after discharge from hospital are rare.
DESIGN
A multicentre follow-up study.
METHODS
This was a multicentre follow-up study of COVID-19 patients who had discharged from six designated hospitals. Physical symptoms and HRQoL were surveyed at first follow-up (the third month after discharge). The latest multiple laboratory findings were collected through medical examination records. This study was performed and reported in accordance with STROBE checklist.
RESULTS
Three hundred eleven patients (57.6%) were reported with one or more physical symptoms. The scores of HRQoL of COVID-19 patients at third month after discharge, except for the dimension of general health, were significantly lower than Chinese population norm (p < .001). Results of logistic regression showed that female (odds ratio (OR): 1.79, 95% confidence interval (CI): 1.04-3.06), older age (≥60 years) (OR: 2.44, 95% CI: 1.33-4.47) and the physical symptom after discharge (OR: 40.15, 95% CI: 9.68-166.49) were risk factors for poor physical component summary; the physical symptom after discharge (OR: 6.68, 95% CI: 4.21-10.59) was a risk factor for poor mental component summary.
CONCLUSIONS
Health-related quality of life of discharged COVID-19 patients did not come back to normal at third month after discharge and affected by age, sex and the physical symptom after discharge.
RELEVANCE TO CLINICAL PRACTICE
Healthcare workers should pay more attention to the physical and psychological rehabilitation of discharged COVID-19 patients. Long-term follow-up on COVID-19 patients after discharge is needed to determine the long-term impact of COVID-19.
目的与目标
确定新冠病毒疾病（COVID-19）出院患者的健康相关生活质量（HRQoL）及其预测因素。
背景
COVID-19已引发全球大流行，并对人类健康和日常生活造成了巨大影响。已有研究表明，住院COVID-19患者的身体和心理状况受到损害，但关注COVID-19出院患者身体和心理状况的研究较少。
设计
一项多中心随访研究。
方法
这是一项对来自六家指定医院的COVID-19出院患者进行的多中心随访研究。在首次随访（出院后第三个月）时对身体症状和HRQoL进行调查。通过医学检查记录收集最新的多项实验室检查结果。本研究按照STROBE清单进行实施和报告。
结果
311名患者（57.6%）报告有一项或多项身体症状。COVID-19患者出院后第三个月的HRQoL评分，除总体健康维度外，均显著低于中国人群常模（p <.001）。逻辑回归结果显示，女性（比值比（OR）：1.79，95%置信区间（CI）：1.04 - 3.06）、年龄较大（≥60岁）（OR：2.44，95% CI：1.33 - 4.47）和出院后身体症状（OR：40.15，95% CI：9.68 - 166.49）是身体成分总结较差的危险因素；出院后身体症状（OR：6.68，95% CI：4.21 - 10.59）是心理成分总结较差的危险因素。
结论
COVID-19出院患者的健康相关生活质量在出院后第三个月未恢复正常，且受年龄、性别和出院后身体症状影响。
与临床实践的相关性
医护人员应更加关注COVID-19出院患者的身体和心理康复。需要对COVID-19出院患者进行长期随访，以确定COVID-19的长期影响。
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