Tapia Vilma L, Vasquez-Apestegui Bertha Vanessa, Alcantara-Zapata Diana, Vu Bryan, Steenland Kyle, Gonzales Gustavo F
Laboratorio de Endocrinología y Reproducción, LID, Universidad Peruana Cayetano Heredia, Lima, Peru.
Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru.
Environ Epidemiol. 2021 Nov 12;5(6):e179. doi: 10.1097/EE9.0000000000000179. eCollection 2021 Dec.
We have previously documented an inverse relationship between PM in Lima, Peru, and reproductive outcomes. Here, we investigate the effect of temperature on birth weight, birth weight-Z-score adjusted for gestational age, low birth weight, and preterm birth. We also explore interactions between PM and temperature.
We studied 123,034 singleton births in three public hospitals of Lima with temperature and PM during gestation between 2012 and 2016. We used linear, logistic, and Cox regression to estimate associations between temperature during gestation and birth outcomes and explored possible modification of the temperature effect by PM.
Exposure to maximum temperature in the last trimester was inversely associated with both birth weight [β: -23.7; 95% confidence interval [CI]: -28.0, -19.5] and z-score weight-for-gestational-age (β: -0.024; 95% CI: -0.029, -0.020) with an interquartile range of 5.32 °C. There was also an increased risk of preterm birth with higher temperature (interquartile range) in the first trimester (hazard ratio: 1.04; 95% CI: 1.001, 1.070). The effect of temperature on birthweight was primarily seen at higher PM levels. There were no statistically significant associations between temperature exposure with low birth weight.
Exposition to maximum temperature was associated with lower birth weight and z-score weight-for-gestational-age and higher risk of preterm birth, in accordance with much of the literature. The effects on birth weight were seen only in the third trimester.
我们之前记录了秘鲁利马的颗粒物（PM）与生殖结局之间的负相关关系。在此，我们研究温度对出生体重、根据胎龄调整的出生体重Z评分、低出生体重和早产的影响。我们还探讨了PM与温度之间的相互作用。
我们研究了2012年至2016年期间利马三家公立医院的123,034例单胎分娩，记录了孕期的温度和PM数据。我们使用线性、逻辑和Cox回归来估计孕期温度与出生结局之间的关联，并探讨PM对温度效应的可能修正作用。
孕晚期暴露于最高温度与出生体重[β：-23.7；95%置信区间（CI）：-28.0，-19.5]和胎龄别体重Z评分（β：-0.024；95%CI：-0.029，-0.020）均呈负相关，四分位间距为5.32℃。孕早期温度较高（四分位间距）时早产风险也增加（风险比：1.04；95%CI：1.001，1.070）。温度对出生体重的影响主要在较高PM水平时出现。温度暴露与低出生体重之间无统计学显著关联。
与许多文献一致，暴露于最高温度与较低的出生体重和胎龄别体重Z评分以及较高的早产风险相关。对出生体重的影响仅在孕晚期出现。
