Jain Harsha, Bhat Aditi Rajan, Dalvi Harshita, Godugu Chandraiah, Singh Shashi Bala, Srivastava Saurabh
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, 500037, India.
Department of Biological Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, 500037, India.
Curr Res Pharmacol Drug Discov. 2021 Jun 9;2:100041. doi: 10.1016/j.crphar.2021.100041. eCollection 2021.
Psoriasis is a chronic inflammatory autoimmune condition manifested by the hyperproliferation of keratinocytes with buildup of inflammatory red patches and scales on skin surfaces. The available treatment options for the management of psoriasis have various drawbacks, and the clinical need for effective therapeutics for this disease remain unmet; therefore, the approaches of drug repurposing or drug repositioning could potentially be used for treating indications of psoriasis. The undiscovered potential of drug repurposing or repositioning compensates for the limitations and hurdles in drug discovery and drug development processes. Drugs initially approved for other indications, including anticancer, antidiabetic, antihypertensive, and anti-arthritic activities, are being investigated for their potential in psoriasis management as a new therapeutic indication by using repurposing strategies. This article envisages the potential of various therapeutics for the management of psoriasis.
银屑病是一种慢性炎症性自身免疫性疾病，表现为角质形成细胞过度增殖，皮肤表面出现炎性红色斑块和鳞屑。目前用于治疗银屑病的方法存在各种缺点，临床上对这种疾病有效治疗药物的需求仍未得到满足；因此，药物重新利用或重新定位的方法可能用于治疗银屑病。药物重新利用或重新定位未被发现的潜力弥补了药物发现和药物开发过程中的局限性和障碍。最初被批准用于其他适应症的药物，包括抗癌、抗糖尿病、抗高血压和抗关节炎活性药物，正通过重新利用策略研究其在银屑病治疗中的潜力，作为一种新的治疗适应症。本文设想了各种疗法在银屑病治疗中的潜力。
