Kimia Andisheh Teb Medical and Molecular Laboratory Research Co., Tehran, Iran.
Department of Dermatology, Tabriz University of Medical Sciences, Tabriz, Iran.
Front Immunol. 2024 Aug 12;15:1416842. doi: 10.3389/fimmu.2024.1416842. eCollection 2024.
Psoriasis, a persistent immune-mediated inflammatory skin condition, affects approximately 2-3% of the global population. Current treatments for psoriasis are fraught with limitations, including adverse effects, high costs, and diminishing efficacy over time. Thymoquinone (TQ), derived from seeds, exhibits promising anti-inflammatory, antioxidant, and immunomodulatory properties that could prove beneficial in managing psoriasis. However, TQ's hydrophobic nature and poor bioavailability have hindered its usefulness as a therapeutic agent. Recent research has strategically addressed these challenges by developing nano-thymoquinone (nano-TQ) formulations to enhance delivery and efficacy in treating psoriasis. Preclinical studies employing mouse models have demonstrated that nano-TQ effectively mitigates inflammation, erythema, scaling, epidermal thickness, and cytokine levels in psoriatic lesions. Various nano-TQ formulations, including nanoemulsions, lipid vesicles, nanostructured lipid carriers, and ethosomes, have been explored to improve solubility, facilitate skin penetration, ensure sustained release, and achieve site-specific targeting. Although clinical trials are currently scarce, the outcomes from and animal models are promising. The potential co-delivery of nano-TQ with other anti-psoriatic agents also presents avenues for further investigation.
银屑病是一种持续存在的免疫介导的炎症性皮肤疾病，影响全球约 2-3%的人口。目前治疗银屑病的方法存在诸多局限性，包括不良反应、高成本和随着时间的推移疗效降低等问题。姜黄素（TQ）来源于 种子，具有有希望的抗炎、抗氧化和免疫调节特性，可能对治疗银屑病有益。然而，TQ 的疏水性和较差的生物利用度阻碍了它作为治疗剂的应用。最近的研究通过开发纳米姜黄素（nano-TQ）制剂来解决这些挑战，以提高在治疗银屑病中的递送和疗效。使用小鼠模型的临床前研究表明，纳米 TQ 可有效减轻炎症、红斑、鳞屑、表皮厚度和银屑病病变中的细胞因子水平。已经探索了各种纳米 TQ 制剂，包括纳米乳剂、脂质体、纳米结构脂质载体和醇质体，以提高溶解度、促进皮肤渗透、确保持续释放和实现靶向特定部位。尽管目前临床研究还很少，但 和动物模型的结果是有希望的。纳米 TQ 与其他抗银屑病药物的联合递送也为进一步研究提供了途径。
