人体测量学临床指标与内脏脂肪蓄积作为非酒精性脂肪性肝病的预测因子。

Anthropometric clinical indicators of visceral adiposity as predictors of nonalcoholic fatty liver disease.

机构信息

Universidade Federal da Bahia, Escola de Nutrição, Departamento de Ciências da Nutrição - Salvador (BA), Brazil.

Universidade Federal da Bahia, Programa de Pós-Graduação em Medicina e Saúde -Salvador (BA), Brazil.

出版信息

Rev Assoc Med Bras (1992). 2021 Nov;67(11):1544-1549. doi: 10.1590/1806-9282.20210316.

DOI:10.1590/1806-9282.20210316

PMID:34909876

Abstract

OBJECTIVE

This study aims to evaluate the role of anthropometric clinical indicators of visceral adiposity as predictors of NAFLD, identifying the cutoff points based on gender.

METHODS

This was a cross-sectional study conducted in patients with or without NAFLD. Waist circumference (WC), body mass index (BMI), waist-to-height ratio (WHtR), Conicity Index (C Index), and lipid accumulation product (LAP) were evaluated.

RESULTS

A total of 107 individuals were evaluated, of which 46.7% were diagnosed with NAFLD. Individuals with NAFLD presented higher values of WC, BMI, C Index, LAP, and WHtR when compared with those without NAFLD (p<0.05). For the total sample, the indicators WC, BMI, WHtR, LAP, and C Index had an area under the receiver operator characteristic curve (AUC) above 0.87, with no difference in the prediction of NAFLD in both sexes. WHtR (AUC=0.934) was the indicator of visceral adiposity with the best discriminatory power for NAFLD, followed by LAP (0.919), WC (0.912), C Index (0.907), and BMI (0.877).

CONCLUSIONS

The anthropometric clinical indicators of visceral adiposity showed high performance, especially the WHtR indicator, as NAFLD predictors.

摘要

目的

本研究旨在评估内脏脂肪肥胖的人体测量临床指标作为非酒精性脂肪性肝病（NAFLD）预测因子的作用，确定基于性别的切点。

方法

这是一项在有或无 NAFLD 的患者中进行的横断面研究。评估了腰围（WC）、体重指数（BMI）、腰高比（WHtR）、圆柱指数（C 指数）和脂质蓄积产物（LAP）。

结果

共评估了 107 人，其中 46.7%被诊断为 NAFLD。与无 NAFLD 的个体相比，患有 NAFLD 的个体的 WC、BMI、C 指数、LAP 和 WHtR 值更高（p<0.05）。对于总样本，WC、BMI、WHtR、LAP 和 C 指数的指标的受试者工作特征曲线（ROC）下面积（AUC）均大于 0.87，且在两性中对 NAFLD 的预测无差异。WHtR（AUC=0.934）是预测 NAFLD 的最佳区分能力的内脏脂肪指标，其次是 LAP（0.919）、WC（0.912）、C 指数（0.907）和 BMI（0.877）。