脂堆积产物（LAP）指数诊断非酒精性脂肪性肝病（NAFLD）：系统评价和荟萃分析。

Lipid accumulation product (LAP) index for the diagnosis of nonalcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis.

机构信息

Endocrinology and Metabolism Research Center (EMRC), School of Medicine, Vali-Asr Hospital, Tehran, P.O. Box 13145784, Iran.

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Lipids Health Dis. 2023 Mar 15;22(1):41. doi: 10.1186/s12944-023-01802-6.

BACKGROUND

Lipid accumulation product (LAP) is an index calculated by waist circumference (WC) and triglyceride (TG), which reflects lipid toxicity. This study aims to investigate the association between the LAP index and nonalcoholic fatty liver disease (NAFLD) in a systematic review and meta-analysis.

METHODS AND RESULTS

PubMed, Scopus, and Web of Science online databases were searched for eligible studies that investigated the association of the LAP index and NAFLD. Sixteen observational studies with 96,101 participants, including four cohort studies, one case‒control study and 11 cross-sectional studies with baseline data, were entered into this analysis. Fourteen studies reported a significant association between the LAP index and NAFLD, and two reported that this relation was not significant; two different meta-analyses (1- mean difference (MD) and 2- bivariate diagnostic test accuracy [DTA]) were conducted using Stata version 14. The LAP index was compared in subjects with and without NAFLD, and the difference was significant with 34.90 units (CI 95: 30.59-39.31, P < 0.001) of the LAP index. The DTA meta-analysis was conducted and showed that the LAP index pooled sensitivity and specificity for screening of NAFLD were 94% (CI95: 72%-99%, I = 99%, P < 0.001) and 85% (CI95: 62%-96%, I = 99%, P < 0.001), respectively.

CONCLUSION

The LAP Index is an inexpensive, sensitive, and specific method to evaluate NAFLD and may be valuable for NAFLD screening.

背景

脂联素（LAP）是通过腰围（WC）和甘油三酯（TG）计算得出的指标，反映了脂质毒性。本研究旨在通过系统评价和荟萃分析来探讨 LAP 指数与非酒精性脂肪性肝病（NAFLD）之间的关系。

方法和结果

在 PubMed、Scopus 和 Web of Science 在线数据库中搜索了评估 LAP 指数与 NAFLD 之间相关性的研究。共有 16 项观察性研究纳入 96101 名参与者，包括 4 项队列研究、1 项病例对照研究和 11 项具有基线数据的横断面研究。其中 14 项研究报告 LAP 指数与 NAFLD 之间存在显著相关性，2 项研究报告两者之间无显著相关性；使用 Stata 版本 14 进行了 2 项不同的荟萃分析（1-均值差（MD）和 2-双变量诊断测试准确性（DTA））。在有和没有 NAFLD 的受试者中比较了 LAP 指数，差异具有统计学意义（LAP 指数相差 34.90 个单位（95%CI：30.59-39.31，P<0.001）。进行了 DTA 荟萃分析，结果显示 LAP 指数用于筛查 NAFLD 的 pooled 敏感度和特异度分别为 94%（95%CI：72%-99%，I²=99%，P<0.001）和 85%（95%CI：62%-96%，I²=99%，P<0.001）。