Universidade Federal Rural de Pernambuco, Recife, PE, Brazil.
Northumbria University, Newcastle upon Tyne, United Kingdom.
Einstein (Sao Paulo). 2021 Dec 10;19:eA06100. doi: 10.31744/einstein_journal/2021AO6100. eCollection 2021.
To examine the impact of hypertension on cardiovascular health in patients with symptomatic peripheral artery disease and to identify factors associated with uncontrolled hypertension.
A cross-sectional study including 251 patients with symptomatic peripheral artery disease (63.9% males, mean age 67±10 years). Following hypertension diagnosis, blood pressure was measured to determine control of hypertension. Arterial stiffness (carotid-femoral pulse wave velocity) and cardiac autonomic modulation (sympathovagal balance) were assessed.
Hypertension was associated with higher carotid-femoral pulse wave velocity, regardless of sex, age, ankle-brachial index, body mass index, walking capacity, heart rate, or comorbidities (ß=2.59±0.76m/s, b=0.318, p=0.003). Patients with systolic blood pressure ≥120mmHg had higher carotid-femoral pulse wave velocity values than normotensive individuals, and hypertensive patients with systolic blood pressure of ≤119mmHg (normotensive: 7.6±2.4m/s=≤119mmHg: 8.1±2.2m/s 120-129mmHg:9.8±2.6m/s=≥130mmHg: 9.9±2.9m/s, p<0.005). Sympathovagal balance was not associated with hypertension (p>0.05).
Hypertensive patients with symptomatic peripheral artery disease have increased arterial stiffness. Arterial stiffness is even greater in patients with uncontrolled high blood pressure.
研究高血压对有症状外周动脉疾病患者心血管健康的影响，并确定与未控制高血压相关的因素。
一项横断面研究纳入了 251 名有症状外周动脉疾病患者（63.9%为男性，平均年龄 67±10 岁）。诊断为高血压后，测量血压以确定高血压的控制情况。评估动脉僵硬度（颈股脉搏波速度）和心脏自主神经调节（交感神经-副交感神经平衡）。
无论性别、年龄、踝肱指数、体重指数、步行能力、心率或合并症如何，高血压均与较高的颈股脉搏波速度相关（ß=2.59±0.76m/s，b=0.318，p=0.003）。收缩压≥120mmHg 的患者颈股脉搏波速度值高于血压正常的患者，而收缩压≤119mmHg 的高血压患者（血压正常：7.6±2.4m/s；收缩压 120-129mmHg：8.1±2.2m/s；收缩压 120-129mmHg：9.8±2.6m/s；收缩压≥130mmHg：9.9±2.9m/s，p<0.005）。交感神经-副交感神经平衡与高血压无关（p>0.05）。
有症状外周动脉疾病的高血压患者动脉僵硬度增加。未控制的高血压患者的动脉僵硬度甚至更大。
