外周动脉疾病患者不同强度体力活动与心血管健康之间的关联：一项观察性研究。
Association between physical activity performed at different intensities and cardiovascular health in patients with peripheral artery disease: an observational study.
作者信息
de Oliveira Max Duarte, Segheto Wellington, Kanegusuku Hélcio, Gerage Aline Mendes, Wolosker Nelson, Correia Marilia de Almeida, Ritti-Dias Raphael Mendes
机构信息
Universidade Nove de Julho, São Paulo, SP, Brazil.
Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
出版信息
Einstein (Sao Paulo). 2024 Sep 30;22:eAO0682. doi: 10.31744/einstein_journal/2024AO0682. eCollection 2024.
BACKGROUND
We examined the sedentary behavior and physical activity of 260 patients with peripheral artery disease. Women engaged in more light physical activity than men did. Light physical activity was associated with lower arterial stiffness in men only, while no significant associations were found between sedentary behavior, moderate-vigorous physical activity, and cardiovascular outcomes.
BACKGROUND
◼ Women with peripheral artery disease exhibited higher blood pressure and arterial stiffness than men.
BACKGROUND
◼ Low levels of physical activity, particularly moderate to vigorous activity, were observed in individuals with peripheral artery disease.
OBJECTIVE
To analyze the association between the time spent in sedentary behavior and physical activity of different intensities with cardiovascular health in men and women with peripheral artery disease.
METHODS
Two hundred and sixty patients with peripheral artery disease and claudication symptoms (65.7% men; 66±1 years; ankle brachial index 0.57±0.18) were evaluated. Physical activity and sedentary behavior were assessed using an accelerometer. Physical activity was classified into light and moderate-vigorous intensities. The cardiovascular outcomes included blood pressure (oscillometric method), cardiac autonomic modulation (heart rate variability), and arterial stiffness (pulse wave velocity).
RESULTS
Women spent more time engaged in light physical activity than men (341±14 min/day versus 306±9 min/day; p=0.040, respectively). There was no significant difference in the time spent on sedentary behavior and moderate-vigorous physical activity. Women had a higher systolic blood pressure (p=0.025), higher augmentation index (p<0.001), and lower sympathovagal balance (p=0.047) than men. Pulse wave velocity was only negatively associated with light physical activity (β= -4.66; 95%CI= -8.57; -0.76) in men. Light and moderate-vigorous physical activity and sedentary behavior were not associated with other cardiovascular outcomes.
CONCLUSION
Higher levels of light physical activity were associated with lower arterial stiffness in men with peripheral artery disease.
背景
我们研究了260例外周动脉疾病患者的久坐行为和身体活动情况。女性进行的轻度身体活动比男性更多。仅在男性中，轻度身体活动与较低的动脉僵硬度相关，而在久坐行为、中度至剧烈身体活动与心血管结局之间未发现显著关联。
背景
◼ 患有外周动脉疾病的女性比男性表现出更高的血压和动脉僵硬度。
背景
◼ 在外周动脉疾病患者中观察到身体活动水平较低，尤其是中度至剧烈活动。
目的
分析外周动脉疾病男性和女性久坐行为时间以及不同强度身体活动与心血管健康之间的关联。
方法
对260例有外周动脉疾病和跛行症状的患者（65.7%为男性；年龄66±1岁；踝臂指数0.57±0.18）进行评估。使用加速度计评估身体活动和久坐行为。身体活动分为轻度和中度至剧烈强度。心血管结局包括血压（示波法）、心脏自主神经调节（心率变异性）和动脉僵硬度（脉搏波速度）。
结果
女性进行轻度身体活动的时间比男性更多（分别为341±14分钟/天和306±9分钟/天；p = 0.040）。在久坐行为和中度至剧烈身体活动时间上没有显著差异。女性的收缩压更高（p = 0.025）、增强指数更高（p < 0.001）且交感神经与迷走神经平衡更低（p = 0.047）。仅在男性中，脉搏波速度与轻度身体活动呈负相关（β = -4.66；95%CI = -8.57；-0.76）。轻度和中度至剧烈身体活动以及久坐行为与其他心血管结局无关。
结论
在外周动脉疾病男性中，较高水平的轻度身体活动与较低的动脉僵硬度相关。
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