Propolis: Chemical Constituents, Plant Origin, and Possible Role in the Prevention and Treatment of Obesity and Diabetes.

Honeybee products are not only beneficial to human health but also important to the food industry. One such product is propolis, a resinous substance that honeybees collect from certain trees and plants and store inside their hives. Although various health benefits of propolis have been reported, the chemical composition of propolis varies greatly depending on the growing region and plant origin. These differences have led to many misconceptions and conflicting research results. In this paper, we review research findings on how the growing region and plant origin of propolis affects its composition. We also discuss trends in research on the antiobesity and antidiabetes effects of propolis as well as recent findings that a major component of Brazilian green propolis modulates adipocyte function. Finally, we discuss challenges to be tackled in future research on the health benefits of propolis and share our perspective on the future of this field.