Zhu Liuying, Zhang Jinwu, Yang Hui, Li Guangyan, Li Hongyan, Deng Zeyuan, Zhang Bing
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, China.
Nanchang Concentric Purple Nest Biological Engineering Co., Ltd., Nanchang, China.
Front Nutr. 2023 Mar 31;10:1066789. doi: 10.3389/fnut.2023.1066789. eCollection 2023.
Obesity, one of the most common nutritional diseases worldwide, can lead to dyslipidemia, high blood sugar, high blood pressure, and inflammation. Some drugs have been developed to ameliorate obesity. However, these drugs may cause serious side effects. Therefore, there is an urgent need for alternative "natural" remedies including propolis. Studies have found that propolis has excellent anti-obesity activity in and models during the past decades, of which polyphenols are the key component in regulating weight loss. This review focused on the different polyphenol compositions of propolis from different regions and plants, the evidence for the anti-obesity effects of different types of propolis and its derivatives, discussed the impact of propolis polyphenols on obesity related signal pathways, and proposed the molecular mechanism of how propolis polyphenols affect these signal pathways. For example, propolis and its derivatives regulate lipid metabolism related proteins, such as PPARα, PPARγ, SREBP-1&2, and HMG CoA etc., destroy the formation of CREB/CRTC2 transcription complex, activate Nrf2 pathway or inhibit protein kinase IKK ε/TBK1, thereby affecting fat production and lipid metabolism; The effects of propolis on adipokines (adiponectin, leptin and inflammatory factors) were discussed. Additionally, the mechanism of polyphenols in propolis promoting the browning of adipose tissues and the relationship between intestinal microorganisms was summarized. These information may be of value to better understand how specific propolis polyphenols interact with specific signaling pathways and help guide the development of new drugs to combat obesity and related metabolic diseases.
肥胖是全球最常见的营养疾病之一，可导致血脂异常、高血糖、高血压和炎症。已经研发了一些药物来改善肥胖状况。然而，这些药物可能会引起严重的副作用。因此，迫切需要包括蜂胶在内的替代性“天然”疗法。在过去几十年中，研究发现蜂胶在动物模型和细胞模型中具有出色的抗肥胖活性，其中多酚是调节体重减轻的关键成分。本综述重点关注不同地区和植物来源蜂胶的不同多酚成分、不同类型蜂胶及其衍生物抗肥胖作用的证据，讨论了蜂胶多酚对肥胖相关信号通路的影响，并提出了蜂胶多酚影响这些信号通路的分子机制。例如，蜂胶及其衍生物调节脂质代谢相关蛋白，如PPARα、PPARγ、SREBP - 1&2和HMG CoA等，破坏CREB/CRTC2转录复合物的形成，激活Nrf2通路或抑制蛋白激酶IKK ε/TBK1，从而影响脂肪生成和脂质代谢；讨论了蜂胶对脂肪因子（脂联素、瘦素和炎症因子）的影响。此外，总结了蜂胶中多酚促进脂肪组织褐变的机制以及与肠道微生物的关系。这些信息可能有助于更好地理解特定的蜂胶多酚如何与特定的信号通路相互作用，并有助于指导开发对抗肥胖及相关代谢疾病的新药。
