Institute of Drug Discovery Technology, Ningbo University, Zhejiang, China.
Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University, Zhejiang, China.
Chem Commun (Camb). 2022 Jan 27;58(9):1306-1309. doi: 10.1039/d1cc05724c.
A robust dearomative denitration of nitroarene derivatives induced by a radical -cyclization process has been developed, delivering valuable phosphonated or trifluoromethylated azaspiro[4.5]trienones with good functional group tolerance. This represents a convenient and powerful approach to activate nitroarenes in a radical manner.
发展了一种通过自由基-环化过程实现的硝芳烃衍生物的强脱芳构化去硝化反应，得到了具有良好官能团耐受性的有价值的膦酸酯或三氟甲基化氮杂螺[4.5]三烯酮。这代表了一种方便而强大的方法，可通过自由基方式激活硝芳烃。
