铜介导的N-苯基肉桂酰胺的α-三氟甲基化反应与去芳构化反应相结合：通向三氟甲基化的1-氮杂螺[4.5]癸烷的途径。
Copper-mediated α-trifluoromethylation of N-phenylcinnamamides coupled with dearomatization: access to trifluoromethylated 1-azaspiro[4.5]decanes.
作者信息
Han Guifang, Wang Qiang, Liu Yuxiu, Wang Qingmin
机构信息
State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University , Tianjin 300071, China.
出版信息
Org Lett. 2014 Nov 21;16(22):5914-7. doi: 10.1021/ol502921a. Epub 2014 Nov 4.
PMID:25366376
Abstract
Copper-mediated intramolecular trifluoromethylation of N-phenylcinnamamides coupled with cyclization and dearomatization was used to construct various trifluoromethylated 1-azaspiro[4.5]decanes in moderate to high yields and with excellent regioselectivity and diastereoselectivity.
摘要
铜介导的N-苯基肉桂酰胺的分子内三氟甲基化反应，结合环化和去芳构化，用于以中等到高的产率、优异的区域选择性和非对映选择性构建各种三氟甲基化的1-氮杂螺[4.5]癸烷。
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