Department of Pathology, Shri Guru Ram Rai Institute of Medical and Health Sciences, Dehradun, Uttrakhand, India.
Cytopathology. 2022 Mar;33(2):176-184. doi: 10.1111/cyt.13089. Epub 2021 Dec 28.
The International System for Reporting Serous Fluid Cytopathology (ISRSFC) standardises the reporting of serous effusion cytology under five categories: Non-Diagnostic (ND), Negative for Malignancy (NFM), Atypia of Undetermined Significance (AUS), Suspicious for Malignancy (SFM), and Malignant (M). Very few studies have been conducted so far to confirm the risk of malignancy of the different categories.
The main objectives of our study were to classify serous effusions according to the ISRSFC categories and assess their risk of malignancy (ROM) and performance parameters.
All serous effusion samples received from January 2019 to December 2020 were reclassified according to the ISRSFC. Using histopathological diagnosis as the gold standard, ROM and performance parameters were calculated.
A total of 831 pleural effusion samples were reclassified as follows: ND, 3 (0.4%); NFM, 635 (76.4%); AUS, 65 (7.8%); SFM, 60 (7.2%); and M, 68 (8.2%). For 457 peritoneal effusion samples, the reclassifications were ND, 5 (1.1%); NFM, 368 (80.5%); AUS, 19 (4.2%); SFM, 17 (3.7%); and M, 48 (10.5%). All 12 (100%) pericardial effusions belonged to the NFM category. The ROM for the ND, NFM, AUS, SRM, and M categories was 0%, 2.1%, 33.3%, 94.1%, 100%, respectively, in pleural effusions, and 50%, 4.8%, 22.2%, 83.3%, 100%, respectively, in peritoneal effusions. The ROM was 0% for NFM in pericardial effusions.
The ISRSFC is an excellent system for accurately classifying serous effusions with greater reproducibility of reports and better communication between pathologist and clinician.
国际浆膜腔液细胞学报告系统（ISRSFC）将浆膜腔液细胞学报告标准化为五个类别：非诊断性（ND）、非恶性（NFM）、意义未明的非典型性（AUS）、疑似恶性（SFM）和恶性（M）。迄今为止，很少有研究证实不同类别浆膜腔液的恶性风险。
本研究的主要目的是根据 ISRSFC 对浆膜腔液进行分类，并评估其恶性风险（ROM）和性能参数。
对 2019 年 1 月至 2020 年 12 月期间收到的所有浆膜腔液样本进行重新分类，根据 ISRSFC 进行分类。使用组织病理学诊断作为金标准，计算 ROM 和性能参数。
共对 831 例胸腔积液样本进行了重新分类：ND，3 例（0.4%）；NFM，635 例（76.4%）；AUS，65 例（7.8%）；SFM，60 例（7.2%）；M，68 例（8.2%）。对于 457 例腹腔积液样本，重新分类为 ND，5 例（1.1%）；NFM，368 例（80.5%）；AUS，19 例（4.2%）；SFM，17 例（3.7%）；M，48 例（10.5%）。所有 12 例（100%）心包积液均属于 NFM 类别。在胸腔积液中，ND、NFM、AUS、SFM 和 M 类别的 ROM 分别为 0%、2.1%、33.3%、94.1%和 100%，在腹腔积液中，ROM 分别为 50%、4.8%、22.2%、83.3%和 100%。在心包积液中，NFM 的 ROM 为 0%。
ISRSFC 是一种出色的浆膜腔液分类系统，具有更高的报告重复性和病理学家与临床医生之间更好的沟通能力。
