Department of Anesthesiology and Perioperative Medicine, University of Rochester, Rochester, NY, United States of America.
Department of Sociology, University at Buffalo, SUNY, Buffalo, NY, United States of America.
PLoS One. 2021 Dec 16;16(12):e0260742. doi: 10.1371/journal.pone.0260742. eCollection 2021.
Peripheral edema (i.e., lower limb swelling) can cause pain, weakness, and limited range of motion. However, few studies have examined its prevalence in the U.S. or its association with demographics, comorbidities, activity, or mobility. This study used data from the Health and Retirement Study, a nationally representative longitudinal survey of U.S. adults (age 51+/ N = 19,988 for 2016), to evaluate time trends and correlates of peripheral edema using weighted descriptive statistics and logistic regressions, respectively. Peripheral edema was assessed with the question "Have you had… // Persistent swelling in your feet or ankles?" The weighted prevalence of edema among older U.S. adults was 19% to 20% between 2000 and 2016. Peripheral edema was associated with older age, female sex, non-white race, low wealth, obesity, diabetes, hypertension, pain, low activity levels, and mobility limitations (odds ratios ranging from 1.2-5.6; p-values ≤0.001). This study provides the first estimates of national prevalence and correlates of peripheral edema among older Americans. Peripheral edema is common and strongly associated with comorbidities, pain, low activity levels, and mobility limitations, and disproportionately affects poorer and minority groups. Peripheral edema should be a focus of future research in order to develop novel and cost-effective interventions.
周围性水肿（即下肢肿胀）可引起疼痛、乏力和运动范围受限。然而，很少有研究调查其在美国的流行程度及其与人口统计学特征、合并症、活动或移动性的关联。本研究使用了来自健康与退休研究（一项针对美国成年人（年龄 51 岁及以上/2016 年 N = 19988）的全国代表性纵向调查）的数据，分别使用加权描述性统计和逻辑回归来评估周围性水肿的时间趋势和相关性。周围性水肿通过以下问题进行评估：“你是否有过……//双脚或脚踝持续肿胀？”在 2000 年至 2016 年期间，美国老年成年人中周围性水肿的加权患病率为 19%至 20%。周围性水肿与年龄较大、女性、非白种人、低财富、肥胖、糖尿病、高血压、疼痛、活动水平低和移动性受限有关（比值比为 1.2-5.6；p 值均≤0.001）。本研究首次提供了美国老年人中周围性水肿的全国患病率和相关性的估计值。周围性水肿很常见，与合并症、疼痛、活动水平低和移动性受限密切相关，并且不成比例地影响到贫困和少数族裔群体。周围性水肿应成为未来研究的重点，以开发新颖且具有成本效益的干预措施。
