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弗朗茨·塔彭纳(1816-1902)及其对结核病的开创性研究。

Franz Tappeiner (1816-1902) and his pioneering studies on tuberculosis.

机构信息

Department of Neurology, Hospital of Merano (SABES-ASDAA), Merano, Italy.

Department of Infectious - Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Verona, Italy.

出版信息

Tuberculosis (Edinb). 2022 Jan;132:102160. doi: 10.1016/j.tube.2021.102160. Epub 2021 Dec 11.

DOI:10.1016/j.tube.2021.102160
PMID:34915344
Abstract

Franz Tappeiner (1816-1902) was an Austrian scientist: physician and anthropologist. He studied medicine at the universities of Prague and Padua, and completed his medical education receiving his doctorate in 1843 in Vienna. Tappeiner investigated the transmission of pulmonary tuberculosis in animal models and he dealt with public health, in particular Merano's welfare and public health regulations. In 1877, in the Anatomical and Pathological Institute of Munich led by the German pathologist Ludwig von Buhl (1816-1880), Tappeiner studied the transmission of pulmonary tuberculosis in animal models, by exposing dogs to sputum of phthisic patients affected by this disease. He was able to show that phthisis and tuberculosis were the same disease, which could be spread through inhalation. These studies were pioneering and preceded by 10 years the discovery of the tuberculosis bacillus by Robert Koch (1843-1910) in 1882. The research activities of Tappeiner were focal in tracking the future path for Koch's discovery and represent milestones in the history of tuberculosis.

摘要

弗朗茨·塔彭纳(1816-1902 年)是一位奥地利科学家:医生和人类学家。他在布拉格和帕多瓦的大学学习医学,并在维也纳完成了医学教育,于 1843 年获得博士学位。塔彭纳在动物模型中研究了肺结核的传播,并从事公共卫生工作,特别是梅拉诺的福利和公共卫生法规。1877 年,在德国病理学家路德维希·冯·比尔(Ludwig von Buhl,1816-1880 年)领导的慕尼黑解剖学和病理学研究所,塔彭纳通过让狗接触患有这种疾病的肺结核患者的痰液,在动物模型中研究了肺结核的传播。他能够证明肺结核和结核病是同一种疾病,可以通过吸入传播。这些研究具有开创性,比罗伯特·科赫(Robert Koch,1843-1910 年)在 1882 年发现结核杆菌早了 10 年。塔彭纳的研究活动集中在追踪科赫发现的未来路径上,是结核病史上的里程碑。

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