Rapoport S I, Horwitz B, Haxby J V, Grady C L
Can J Neurol Sci. 1986 Nov;13(4 Suppl):540-5. doi: 10.1017/s0317167100037288.
Evidence indicates that Alzheimer's disease (AD) causes functional disconnection of neocortical association areas. In midly demented AD patients without measurable neocortically-mediated cognitive abnormalities, positron emission tomography demonstrates reduced parietal lobe glucose metabolism and left/right metabolic asymmetries in neocortical association areas. Similar metabolic abnormalities occur in moderately demented patients, but are accompanied by appropriate language and visuospatial discrepancies. Left/right metabolic asymmetries correspond with reduced numbers of partial correlations between metabolic rates in homologous right and left regions, and in the frontal and parietal cortices, indicating metabolic uncoupling among these regions. The affected association regions are those which demonstrate Alzheimer-type neuropathology post-mortem.
有证据表明，阿尔茨海默病（AD）会导致新皮质联合区域的功能脱节。在没有可测量的新皮质介导的认知异常的轻度痴呆AD患者中，正电子发射断层扫描显示顶叶葡萄糖代谢降低，以及新皮质联合区域的左右代谢不对称。类似的代谢异常也出现在中度痴呆患者中，但同时伴有相应的语言和视觉空间差异。左右代谢不对称与左右同源区域以及额叶和顶叶皮质代谢率之间的偏相关数量减少相对应，表明这些区域之间存在代谢解偶联。受影响的联合区域是那些在尸检时表现出阿尔茨海默型神经病理学特征的区域。
