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本文引用的文献

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Metabolic disturbances in exo-focal brain areas after cortical stroke studied by positron emission tomography.通过正电子发射断层扫描研究皮质中风后远隔脑区的代谢紊乱。
J Neurol Sci. 1994 May;123(1-2):147-53. doi: 10.1016/0022-510x(94)90217-8.
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Regional cerebral oxygen supply and utilization in dementia. A clinical and physiological study with oxygen-15 and positron tomography.痴呆症患者大脑局部的氧供应与利用：一项使用氧-15和正电子断层扫描技术的临床与生理学研究
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Regional cortical dysfunction in Alzheimer's disease as determined by positron emission tomography.通过正电子发射断层扫描确定的阿尔茨海默病中的局部皮质功能障碍。
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Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease.阿尔茨海默病的临床诊断：美国国立神经疾病与中风研究所-阿尔茨海默病及相关疾病协会工作组在卫生与公众服务部阿尔茨海默病特别工作组主持下的报告。
Neurology. 1984 Jul;34(7):939-44. doi: 10.1212/wnl.34.7.939.
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Ventricular size in patients with presenile dementia of the Alzheimer's type.阿尔茨海默型早老性痴呆患者的脑室大小
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Clinical history, brain metabolism, and neuropsychological function in Alzheimer's disease.阿尔茨海默病的临床病史、脑代谢及神经心理功能
Ann Neurol. 1985 Sep;18(3):298-309. doi: 10.1002/ana.410180305.
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Differences in lateral hemispheric asymmetries of glucose utilization between early- and late-onset Alzheimer-type dementia.早发性和晚发性阿尔茨海默病型痴呆症之间葡萄糖利用的半球侧不对称性差异。
Am J Psychiatry. 1985 May;142(5):638-40. doi: 10.1176/ajp.142.5.638.
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CT in the differential diagnosis between Alzheimer's disease and vascular dementia.CT在阿尔茨海默病与血管性痴呆鉴别诊断中的应用
Acta Neurol Scand. 1987 Apr;75(4):262-70. doi: 10.1111/j.1600-0404.1987.tb07931.x.
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Alzheimer's disease: metabolic uncoupling of associative brain regions.阿尔茨海默病：关联脑区的代谢解偶联
Can J Neurol Sci. 1986 Nov;13(4 Suppl):540-5. doi: 10.1017/s0317167100037288.
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Neocortical metabolic abnormalities precede nonmemory cognitive defects in early Alzheimer's-type dementia.在早期阿尔茨海默病型痴呆中，新皮质代谢异常先于非记忆性认知缺陷出现。
Arch Neurol. 1986 Sep;43(9):882-5. doi: 10.1001/archneur.1986.00520090022010.

如MRI和PET所示，皮质葡萄糖代谢降低与阿尔茨海默病中的海马萎缩相关。

Decreased cortical glucose metabolism correlates with hippocampal atrophy in Alzheimer's disease as shown by MRI and PET.

作者信息

Yamaguchi S, Meguro K, Itoh M, Hayasaka C, Shimada M, Yamazaki H, Yamadori A

机构信息

Division of Disability Science, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan.

出版信息

J Neurol Neurosurg Psychiatry. 1997 Jun;62(6):596-600. doi: 10.1136/jnnp.62.6.596.

DOI:10.1136/jnnp.62.6.596
PMID:9219745
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1074143/
Abstract

OBJECTIVE

To investigate the relation between atrophy of the hippocampus and parahippocampal gyrus (the % hippocampal area) and cerebral metabolic rate for glucose (CMRGlc) in Alzheimer's disease.

METHODS

13 patients with probable Alzheimer's disease by NINCDS-ADRDA criteria (six men; seven women, mean age 71 years, mini mental state 13.8 (SD 4.6)) and age matched controls were studied. T1 weighted MRI (0.5T) images were used for evaluation of the hippocampal area. With a digitiser system, a percentage of the hippocampal area to the brain (the % hippocampal area) was calculated. Eight patients received another T1 weighted MRI (1.5T) for further evaluation of the minimum thickness of the hippocampus. Regional CMRGlc (rCMRGlc) was measured using PET and the FDG technique.

RESULTS

The hippocampal area in patients with Alzheimer's disease was significantly lower than that of controls (P < 0.01). All the cortical rCMRGlc values in patients with Alzheimer's disease were lower than those of controls (P < 0.01). A significant correlation (P < 0.05) was found between the % hippocampal area and rCMRGlc in the temporal lobe, temporoparieto-occipital (TPO) region, and frontal lobe in Alzheimer's disease. There was a significant correlation between minimal hippocampal thickness and ipsilateral TPO metabolism on both sides.

CONCLUSION

The ipsilateral correlation between hippocampal atrophy and decreased TPO metabolism in Alzheimer's disease suggests a functional relation and the asymmetries show that Alzheimer's disease is an asymmetric disease in its early stages.

摘要

目的

研究阿尔茨海默病中海马体和海马旁回萎缩（海马体面积百分比）与脑葡萄糖代谢率（CMRGlc）之间的关系。

方法

对13例符合NINCDS - ADRDA标准的可能患有阿尔茨海默病的患者（6名男性；7名女性，平均年龄71岁，简易精神状态评分为13.8（标准差4.6））以及年龄匹配的对照组进行研究。使用T1加权MRI（0.5T）图像评估海马体面积。通过数字化仪系统计算海马体面积占大脑的百分比（海马体面积百分比）。8例患者接受了另一次T1加权MRI（1.5T）检查，以进一步评估海马体的最小厚度。使用PET和FDG技术测量局部脑葡萄糖代谢率（rCMRGlc）。

结果

阿尔茨海默病患者的海马体面积显著低于对照组（P < 0.01）。阿尔茨海默病患者所有皮质rCMRGlc值均低于对照组（P < 0.01）。在阿尔茨海默病患者中，海马体面积百分比与颞叶、颞顶枕（TPO）区域和额叶的rCMRGlc之间存在显著相关性（P < 0.05）。两侧海马体最小厚度与同侧TPO代谢之间存在显著相关性。

结论

阿尔茨海默病中海马体萎缩与TPO代谢降低之间的同侧相关性表明存在功能关系，且不对称性表明阿尔茨海默病在早期是一种不对称性疾病。