如MRI和PET所示，皮质葡萄糖代谢降低与阿尔茨海默病中的海马萎缩相关。
Decreased cortical glucose metabolism correlates with hippocampal atrophy in Alzheimer's disease as shown by MRI and PET.
作者信息
Yamaguchi S, Meguro K, Itoh M, Hayasaka C, Shimada M, Yamazaki H, Yamadori A
机构信息
Division of Disability Science, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan.
出版信息
J Neurol Neurosurg Psychiatry. 1997 Jun;62(6):596-600. doi: 10.1136/jnnp.62.6.596.
OBJECTIVE
To investigate the relation between atrophy of the hippocampus and parahippocampal gyrus (the % hippocampal area) and cerebral metabolic rate for glucose (CMRGlc) in Alzheimer's disease.
METHODS
13 patients with probable Alzheimer's disease by NINCDS-ADRDA criteria (six men; seven women, mean age 71 years, mini mental state 13.8 (SD 4.6)) and age matched controls were studied. T1 weighted MRI (0.5T) images were used for evaluation of the hippocampal area. With a digitiser system, a percentage of the hippocampal area to the brain (the % hippocampal area) was calculated. Eight patients received another T1 weighted MRI (1.5T) for further evaluation of the minimum thickness of the hippocampus. Regional CMRGlc (rCMRGlc) was measured using PET and the FDG technique.
RESULTS
The hippocampal area in patients with Alzheimer's disease was significantly lower than that of controls (P < 0.01). All the cortical rCMRGlc values in patients with Alzheimer's disease were lower than those of controls (P < 0.01). A significant correlation (P < 0.05) was found between the % hippocampal area and rCMRGlc in the temporal lobe, temporoparieto-occipital (TPO) region, and frontal lobe in Alzheimer's disease. There was a significant correlation between minimal hippocampal thickness and ipsilateral TPO metabolism on both sides.
CONCLUSION
The ipsilateral correlation between hippocampal atrophy and decreased TPO metabolism in Alzheimer's disease suggests a functional relation and the asymmetries show that Alzheimer's disease is an asymmetric disease in its early stages.
目的
研究阿尔茨海默病中海马体和海马旁回萎缩（海马体面积百分比）与脑葡萄糖代谢率（CMRGlc）之间的关系。
方法
对13例符合NINCDS - ADRDA标准的可能患有阿尔茨海默病的患者（6名男性；7名女性，平均年龄71岁，简易精神状态评分为13.8（标准差4.6））以及年龄匹配的对照组进行研究。使用T1加权MRI（0.5T）图像评估海马体面积。通过数字化仪系统计算海马体面积占大脑的百分比（海马体面积百分比）。8例患者接受了另一次T1加权MRI（1.5T）检查，以进一步评估海马体的最小厚度。使用PET和FDG技术测量局部脑葡萄糖代谢率（rCMRGlc）。
结果
阿尔茨海默病患者的海马体面积显著低于对照组（P < 0.01）。阿尔茨海默病患者所有皮质rCMRGlc值均低于对照组（P < 0.01）。在阿尔茨海默病患者中，海马体面积百分比与颞叶、颞顶枕（TPO）区域和额叶的rCMRGlc之间存在显著相关性（P < 0.05）。两侧海马体最小厚度与同侧TPO代谢之间存在显著相关性。
结论
阿尔茨海默病中海马体萎缩与TPO代谢降低之间的同侧相关性表明存在功能关系，且不对称性表明阿尔茨海默病在早期是一种不对称性疾病。
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