Araki S, Chikazawa K, Sekiguchi I, Yamauchi H, Motoyama M, Tamada T
Fertil Steril. 1987 Jan;47(1):169-72. doi: 10.1016/s0015-0282(16)49955-3.
The degree of follicular development was examined in a patient with 17 alpha-hydroxylase deficiency that accounted for impairment of estrogen and androgen biosynthesis. The ovarian content of P was markedly higher than those of any other steroids requiring 17 alpha-hydroxylation for synthesis. The morphologic analysis of the ovaries demonstrated that normal follicles could not develop to more than 2.2 mm in diameter, and most follicles with diameters of 1.0 mm or more yielded to atresia. It is known that estrogen and FSH act synergistically on the growth of the follicles. Our data suggest that the follicles can develop up to the size of 2.2 mm in diameter at most with the sole stimulation of gonadotropin.
对一名患有17α-羟化酶缺乏症的患者进行了卵泡发育程度检查，该病症导致雌激素和雄激素生物合成受损。卵巢中P的含量明显高于任何其他需要17α-羟化才能合成的类固醇。卵巢的形态学分析表明，正常卵泡直径无法发育至超过2.2毫米，大多数直径为1.0毫米或更大的卵泡会闭锁。已知雌激素和促卵泡生成素（FSH）对卵泡生长起协同作用。我们的数据表明，在仅由促性腺激素刺激的情况下，卵泡最多只能发育到直径2.2毫米大小。
